ENSMUSG00000025969


Mus musculus

Features
Gene ID: ENSMUSG00000025969
  
Biological name :Nrp2
  
Synonyms : Neuropilin-2 / Nrp2 / O35375
  
Possible biological names infered from orthology : O60462
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 62703285
Gene end: 62818695
  
Corresponding Affymetrix probe sets: 10346843 (MoGene1.0st)   1426528_at (Mouse Genome 430 2.0 Array)   1435349_at (Mouse Genome 430 2.0 Array)   1447343_at (Mouse Genome 430 2.0 Array)   1456778_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027112
Ensembl peptide - ENSMUSP00000069379
Ensembl peptide - ENSMUSP00000074642
Ensembl peptide - ENSMUSP00000109792
Ensembl peptide - ENSMUSP00000109794
Ensembl peptide - ENSMUSP00000099886
NCBI entrez gene - 18187     See in Manteia.
MGI - MGI:1100492
RefSeq - NM_001077406
RefSeq - NM_001077403
RefSeq - NM_001077404
RefSeq - NM_001077405
RefSeq - NM_001077407
RefSeq - NM_010939
RefSeq Peptide - NP_001070871
RefSeq Peptide - NP_001070872
RefSeq Peptide - NP_001070873
RefSeq Peptide - NP_001070874
RefSeq Peptide - NP_001070875
RefSeq Peptide - NP_035069
swissprot - O35375
swissprot - Q3U5I8
swissprot - Q8QZY7
Ensembl - ENSMUSG00000025969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRP2ENSGALG00000008621Gallus gallus
 NRP2ENSG00000118257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG0000002581045
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657918
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119618
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG0000003448814
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG0000003060513
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG0000003510713
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG000000312098
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG000000036178
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG000000319368
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198917
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG000000312936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027143  Neuropilin-2
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007507 heart development IGI
 biological_processGO:0021612 facial nerve structural organization IMP
 biological_processGO:0021649 vestibulocochlear nerve structural organization IMP
 biological_processGO:0021675 nerve development IMP
 biological_processGO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0036486 ventral trunk neural crest cell migration IMP
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0048846 axon extension involved in axon guidance IMP
 biological_processGO:0050919 negative chemotaxis IMP
 biological_processGO:0061549 sympathetic ganglion development IMP
 biological_processGO:0061551 trigeminal ganglion development IMP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0097374 sensory neuron axon guidance IMP
 biological_processGO:0097490 sympathetic neuron projection extension IMP
 biological_processGO:0097491 sympathetic neuron projection guidance IMP
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development IMP
 biological_processGO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
 biological_processGO:1903375 facioacoustic ganglion development IMP
 biological_processGO:1904835 dorsal root ganglion morphogenesis IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2+
Genetic Background: involves: C57BL/6

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chn2tm2.1Alk/Chn2+,Nrp2Gt(GST039)Byg/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Ednrbs-15DttMb/Ednrbs-15DttMb
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Nrp2tm1.2Mom/Nrp2tm1.2Mom,Vmn1r49tm1Mom/Vmn1r49tm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0001061 abnormal oculomotor nerve morphology "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001064 absent trochlear nerve "missing nerve of the superior oblique muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Kdrtm1.1Eia/Kdrtm1.1Eia
Genetic Background: B6.129P2-Kdrtm1.1Eia

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1Kmf/Y
Genetic Background: involves: C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S6/SvEvTac

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004082 abnormal habenula development "anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004106 lymphatic vessel hyperplasia "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1Kmf/Y
Genetic Background: involves: C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
Show

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2+
Genetic Background: involves: C57BL/6

Allelic Composition: Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp2tm1.2Mom/Nrp2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

 MP:0009939 abnormal hippocampus neuron morphology 
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0010197 abnormal lymphatic vessel endothelial cell morphology "any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1Kmf/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Nrp2tm1.2Mom/Nrp2+,Sema3ftm1.2Ddg/Sema3f+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010368 abnormal lymphatic system physiology "any functional anomaly of the interconnected system of spaces, organs and vessels between body tissues and organs through which fluid, fats, proteins, and lymphocytes are transported to the bloodstream as lymph, and microorganisms and other debris are removed from tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1Kmf/Y
Genetic Background: involves: C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2+
Genetic Background: involves: C57BL/6

 MP:0011678 abnormal vomeronasal sensory neuron physiology "any functional anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MGI:csmith]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0011679 abnormal vomeronasal sensory neuron morphology "any structural anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MGI:csmith]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0012014 abnormal olfactory neuron innervation pattern "any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb" [MGI:csmith]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020598 Nrcam / Q810U4 / Neuronal cell adhesion molecule / Q92823*  / complex / reaction
 ENSMUSG00000025969 Nrp2 / O35375 / Neuropilin-2 / O60462*  / complex / reaction
 ENSMUSG00000029648 Flt1 / fms related tyrosine kinase 1 / P17948*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr