ENSMUSG00000020598


Mus musculus

Features
Gene ID: ENSMUSG00000020598
  
Biological name :Nrcam
  
Synonyms : Neuronal cell adhesion molecule / Nrcam / Q810U4
  
Possible biological names infered from orthology : Q92823
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: B2
Gene start: 44328885
Gene end: 44601964
  
Corresponding Affymetrix probe sets: 10395553 (MoGene1.0st)   1430583_at (Mouse Genome 430 2.0 Array)   1434709_at (Mouse Genome 430 2.0 Array)   1443281_at (Mouse Genome 430 2.0 Array)   1458833_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151243
Ensembl peptide - ENSMUSP00000106376
Ensembl peptide - ENSMUSP00000151296
Ensembl peptide - ENSMUSP00000152002
Ensembl peptide - ENSMUSP00000151873
Ensembl peptide - ENSMUSP00000151844
Ensembl peptide - ENSMUSP00000151824
Ensembl peptide - ENSMUSP00000151732
Ensembl peptide - ENSMUSP00000151475
Ensembl peptide - ENSMUSP00000151419
Ensembl peptide - ENSMUSP00000020939
NCBI entrez gene - 319504     See in Manteia.
MGI - MGI:104750
RefSeq - XM_017315104
RefSeq - XM_017315092
RefSeq - XM_017315093
RefSeq - XM_017315094
RefSeq - XM_017315095
RefSeq - XM_017315096
RefSeq - XM_017315097
RefSeq - XM_017315098
RefSeq - XM_017315099
RefSeq - XM_017315100
RefSeq - XM_017315101
RefSeq - XM_017315102
RefSeq - XM_017315103
RefSeq - NM_001146031
RefSeq - NM_176930
RefSeq - XM_006515944
RefSeq - XM_006515945
RefSeq - XM_006515946
RefSeq - XM_006515947
RefSeq - XM_006515948
RefSeq - XM_006515949
RefSeq - XM_006515950
RefSeq - XM_006515951
RefSeq - XM_006515952
RefSeq - XM_006515953
RefSeq - XM_006515954
RefSeq - XM_006515955
RefSeq - XM_006515956
RefSeq - XM_006515957
RefSeq - XM_006515958
RefSeq - XM_006515959
RefSeq - XM_006515960
RefSeq - XM_006515961
RefSeq - XM_006515962
RefSeq - XM_006515963
RefSeq - XM_006515964
RefSeq - XM_006515965
RefSeq - XM_006515966
RefSeq - XM_006515967
RefSeq - XM_006515968
RefSeq - XM_006515969
RefSeq - XM_017315089
RefSeq - XM_017315090
RefSeq - XM_017315091
RefSeq Peptide - NP_001139503
RefSeq Peptide - NP_795904
swissprot - A0A1W2P7Y9
swissprot - A0A1W2P7X4
swissprot - A0A1W2P7R6
swissprot - A0A1W2P6Z1
swissprot - A0A1W2P8F5
swissprot - A0A1W2P6P3
swissprot - Q810U4
swissprot - A0A1W2P6F8
swissprot - A0A1W2P6V1
swissprot - A0A1W2P814
Ensembl - ENSMUSG00000020598
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrcamaENSDARG00000006396Danio rerio
 NRCAMENSGALG00000009514Gallus gallus
 NRCAMENSG00000091129Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfasc / Q810U3 / Neurofascin / O94856*ENSMUSG0000002644246
Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*ENSMUSG0000003007740
L1cam / L1 cell adhesion molecule / P32004*ENSMUSG0000003139139
Cntn3 / Q07409 / Contactin-3 / Q9P232*ENSMUSG0000003007523
Cntn2 / Q61330 / Contactin-2 / Q02246*ENSMUSG0000005302422
Cntn6 / Q9JMB8 / Contactin-6 / Q9UQ52*ENSMUSG0000003009222
Cntn1 / P12960 / Mus musculus contactin 1 (Cntn1), transcript variant 4, mRNA. / Q12860* / contactin 1*ENSMUSG0000005502222
Cntn4 / Q69Z26 / Contactin-4 / Q8IWV2*ENSMUSG0000006429322
Cntn5 / P68500 / Contactin-5 / O94779*ENSMUSG0000003948822


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026966  Neurofascin/L1/NrCAM, C-terminal domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007417 central nervous system development IDA
 biological_processGO:0008104 protein localization IDA
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0019227 neuronal action potential propagation IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0045162 clustering of voltage-gated sodium channels IEA
 biological_processGO:0098609 cell-cell adhesion IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0086080 protein binding involved in heterotypic cell-cell adhesion IGI


Pathways (from Reactome)
Pathway description
Neurofascin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele,Gldntm1Pele/Gldntm1Pele
Genetic Background: involves: ICR

Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Lpin1fld/Lpin1fld,Nrcam20884/Nrcam20884
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Lpin1fld/Lpin1fld,Nrcam20884/Nrcam20884
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrcamm1J/Nrcamm1J
Genetic Background: B6.Cg-Nrcamm1J/GrsrRwb

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Nrcamm1J/Nrcamm1J
Genetic Background: B6.Cg-Nrcamm1J/GrsrRwb

Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Nrcamm1Btlr/Nrcamm1Btlr
Genetic Background: C57BL/6J-Nrcamm1Btlr

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: a16H/a16H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lpin120884/Lpin1fld
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcam+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrcamm1J/Nrcamm1J
Genetic Background: B6.Cg-Nrcamm1J/GrsrRwb

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a16H/a16H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: EdaTa-32H/Y
Genetic Background: Not Specified

Allelic Composition: Nfasctm1.1Brp/Nfasctm1.1Brp,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * ICR

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Nrcamm1J/Nrcamm1J
Genetic Background: B6.Cg-Nrcamm1J/GrsrRwb

Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ehmt1tm1Yshk/Ehmt1+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Lpin1fld/Lpin1fld,Nrcam20884/Nrcam20884
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Lpin120884/Lpin120884,Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

Allelic Composition: Nrcam20884/Nrcam20884
Genetic Background: involves: C57BL/6J

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0010559 heart block "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrcamm1J/Nrcamm1J
Genetic Background: B6.Cg-Nrcamm1J/GrsrRwb

Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb

 MP:0010732 abnormal node of Ranvier morphology "any structural anomaly of the short unmyelinated segments of an axon between myelinated segments, where voltage gated channels accumulate and regenerate an action potential as it is conducted along the axon" [PMID:18929652]
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Allelic Composition: Nrcamm1J/Nrcamm1J
Genetic Background: B6.Cg-Nrcamm1J/GrsrRwb

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele,Nrcamtm1Gmt/Nrcamtm1Gmt
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzr1Gt(RRJ067)Byg/Fzr1Gt(RRJ067)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: L1camtm1Sor/Y,Nrcamtm1Gmt/Nrcam+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022770 Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*  / reaction / complex
 ENSMUSG00000025969 Nrp2 / O35375 / Neuropilin-2 / O60462*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000026442 Nfasc / Q810U3 / Neurofascin / O94856*  / reaction / complex
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / reaction / complex






 

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