ENSG00000091129


Homo sapiens

Features
Gene ID: ENSG00000091129
  
Biological name :NRCAM
  
Synonyms : neuronal cell adhesion molecule / NRCAM / Q92823
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.1
Gene start: 108147623
Gene end: 108456717
  
Corresponding Affymetrix probe sets: 204105_s_at (Human Genome U133 Plus 2.0 Array)   216959_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393663
Ensembl peptide - ENSP00000390868
Ensembl peptide - ENSP00000397544
Ensembl peptide - ENSP00000484840
Ensembl peptide - ENSP00000408203
Ensembl peptide - ENSP00000407858
Ensembl peptide - ENSP00000401244
Ensembl peptide - ENSP00000398174
Ensembl peptide - ENSP00000325269
Ensembl peptide - ENSP00000368308
Ensembl peptide - ENSP00000368310
Ensembl peptide - ENSP00000368314
Ensembl peptide - ENSP00000390421
NCBI entrez gene - 4897     See in Manteia.
OMIM - 601581
RefSeq - XM_017012259
RefSeq - XM_017012245
RefSeq - XM_017012246
RefSeq - XM_017012247
RefSeq - XM_017012248
RefSeq - XM_017012249
RefSeq - XM_017012250
RefSeq - XM_017012251
RefSeq - XM_017012252
RefSeq - XM_017012253
RefSeq - XM_017012254
RefSeq - XM_017012255
RefSeq - XM_017012256
RefSeq - XM_017012257
RefSeq - XM_017012258
RefSeq - NM_001037132
RefSeq - NM_001193582
RefSeq - NM_001193583
RefSeq - NM_001193584
RefSeq - NM_005010
RefSeq - XM_005250373
RefSeq - XM_005250383
RefSeq - XM_005250385
RefSeq - XM_006716003
RefSeq - XM_006716007
RefSeq - XM_006716012
RefSeq - XM_006716014
RefSeq - XM_011516253
RefSeq - XM_011516255
RefSeq - XM_011516256
RefSeq - XM_011516257
RefSeq - XM_011516258
RefSeq - XM_011516259
RefSeq - XM_011516261
RefSeq - XM_011516262
RefSeq - XM_011516265
RefSeq - XM_011516266
RefSeq - XM_011516267
RefSeq - XM_011516268
RefSeq - XM_011516269
RefSeq - XM_011516270
RefSeq - XM_011516271
RefSeq - XM_017012236
RefSeq - XM_017012237
RefSeq - XM_017012238
RefSeq - XM_017012239
RefSeq - XM_017012240
RefSeq - XM_017012241
RefSeq - XM_017012242
RefSeq - XM_017012243
RefSeq - XM_017012244
RefSeq Peptide - NP_001180511
RefSeq Peptide - NP_001180512
RefSeq Peptide - NP_001180513
RefSeq Peptide - NP_005001
RefSeq Peptide - NP_001032209
swissprot - F8W775
swissprot - H7C132
swissprot - Q92823
swissprot - A0A087X2B3
swissprot - C9JYY6
swissprot - C9JUR7
swissprot - C9JH43
swissprot - C9JF43
swissprot - C9J8B6
Ensembl - ENSG00000091129
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrcamaENSDARG00000006396Danio rerio
 NRCAMENSGALG00000009514Gallus gallus
 NrcamENSMUSG00000020598Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFASC / O94856 / neurofascinENSG0000016353145
L1CAM / P32004 / L1 cell adhesion moleculeENSG0000019891038
CHL1 / O00533 / cell adhesion molecule L1 likeENSG0000013412138
CNTN6 / Q9UQ52 / contactin 6ENSG0000013411522
CNTN5 / O94779 / contactin 5ENSG0000014997222
CNTN3 / Q9P232 / contactin 3ENSG0000011380522
CNTN4 / Q8IWV2 / contactin 4ENSG0000014461922
CNTN2 / Q02246 / contactin 2ENSG0000018414421
CNTN1 / Q12860 / contactin 1ENSG0000001823620


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026966  Neurofascin/L1/NrCAM, C-terminal domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEP
 biological_processGO:0001764 neuron migration NAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007409 axonogenesis NAS
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007413 axonal fasciculation NAS
 biological_processGO:0007416 synapse assembly TAS
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0019227 neuronal action potential propagation IEA
 biological_processGO:0030516 regulation of axon extension NAS
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0045162 clustering of voltage-gated sodium channels IEA
 biological_processGO:0045666 positive regulation of neuron differentiation NAS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0009897 external side of plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection NAS
 cellular_componentGO:0043194 axon initial segment ISS
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030506 ankyrin binding IDA
 molecular_functionGO:0086080 protein binding involved in heterotypic cell-cell adhesion IEA


Pathways (from Reactome)
Pathway description
Interaction between L1 and Ankyrins
NrCAM interactions
Neurofascin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex / reaction
 ENSG00000145362 ANK2 / Q01484 / ankyrin 2  / complex
 ENSG00000029534 ANK1 / P16157 / ankyrin 1  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000163531 NFASC / O94856 / neurofascin  / complex / reaction
 ENSG00000184144 CNTN2 / Q02246 / contactin 2  / reaction / complex
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex
 ENSG00000075043 KCNQ2 / O43526 / potassium voltage-gated channel subfamily Q member 2  / reaction / complex
 ENSG00000105711 SCN1B / Q07699 / sodium voltage-gated channel beta subunit 1  / complex / reaction
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / complex
 ENSG00000184156 KCNQ3 / O43525 / potassium voltage-gated channel subfamily Q member 3  / complex / reaction
 ENSG00000183873 SCN5A / Q14524 / sodium voltage-gated channel alpha subunit 5  / complex / reaction
 ENSG00000118257 NRP2 / O60462 / neuropilin 2  / complex / reaction
 ENSG00000163554 SPTA1 / P02549 / spectrin alpha, erythrocytic 1  / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / complex






 

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