ENSMUSG00000053024


Mus musculus

Features
Gene ID: ENSMUSG00000053024
  
Biological name :Cntn2
  
Synonyms : Cntn2 / Contactin-2 / Q61330
  
Possible biological names infered from orthology : Q02246
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 132509427
Gene end: 132543256
  
Corresponding Affymetrix probe sets: 10357705 (MoGene1.0st)   1435165_at (Mouse Genome 430 2.0 Array)   1435166_at (Mouse Genome 430 2.0 Array)   1450523_at (Mouse Genome 430 2.0 Array)   1456962_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083707
Ensembl peptide - ENSMUSP00000141179
Ensembl peptide - ENSMUSP00000140306
Ensembl peptide - ENSMUSP00000139897
Ensembl peptide - ENSMUSP00000139795
NCBI entrez gene - 21367     See in Manteia.
MGI - MGI:104518
RefSeq - XM_006529362
RefSeq - NM_177129
RefSeq Peptide - NP_796103
swissprot - A0A087WPI9
swissprot - A0A087WQQ9
swissprot - A0A087WST5
swissprot - Q61330
swissprot - A0A087WPS6
Ensembl - ENSMUSG00000053024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cntn2ENSDARG00000000472Danio rerio
 CNTN2ENSGALG00000000653Gallus gallus
 CNTN2ENSG00000184144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cntn1 / P12960 / Mus musculus contactin 1 (Cntn1), transcript variant 4, mRNA. / Q12860* / contactin 1*ENSMUSG0000005502249
Cntn6 / Q9JMB8 / Contactin-6 / Q9UQ52*ENSMUSG0000003009242
Cntn3 / Q07409 / Contactin-3 / Q9P232*ENSMUSG0000003007542
Cntn4 / Q69Z26 / Contactin-4 / Q8IWV2*ENSMUSG0000006429342
Cntn5 / P68500 / Contactin-5 / O94779*ENSMUSG0000003948842
L1cam / L1 cell adhesion molecule / P32004*ENSMUSG0000003139128
Nrcam / Q810U4 / Neuronal cell adhesion molecule / Q92823*ENSMUSG0000002059827
Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*ENSMUSG0000003007726
Nfasc / Q810U3 / Neurofascin / O94856*ENSMUSG0000002644224


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032991  Contactin-2
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0010769 regulation of cell morphogenesis involved in differentiation IMP
 biological_processGO:0010954 positive regulation of protein processing IDA
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration IMP
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0031133 regulation of axon diameter IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0045163 clustering of voltage-gated potassium channels IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IGI
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048710 regulation of astrocyte differentiation IMP
 biological_processGO:0060168 positive regulation of adenosine receptor signaling pathway IMP
 biological_processGO:0071205 protein localization to juxtaparanode region of axon IGI
 biological_processGO:0071206 establishment of protein localization to juxtaparanode region of axon IDA
 biological_processGO:0097090 presynaptic membrane organization IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0033268 node of Ranvier IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044224 juxtaparanode region of axon IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IDA
 molecular_functionGO:0043621 protein self-association IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000576 clubbed feet "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000778 abnormal tract 
Show

Allelic Composition: Rtel1tm2.1Pml/Rtel1tm2.1Pml
Genetic Background: 129.129P2(B6)-Rtel1tm2.1Pml

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: Not Specified

Allelic Composition: Cntn2tm1Furl/Cntn2tm1Furl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Fahtm1Mgo/Fahtm1Mgo
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

 MP:0004103 abnormal ventral striatum morphology "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: Not Specified

Allelic Composition: Cntn2tm1Furl/Cntn2tm1Furl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: Not Specified

Allelic Composition: Cntn2tm1Furl/Cntn2tm1Furl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+
Genetic Background: involves: 129S1/Sv * A/J * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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