ENSMUSG00000035107


Mus musculus

Features
Gene ID: ENSMUSG00000035107
  
Biological name :Dcbld2
  
Synonyms : Dcbld2 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q91ZV3
  
Possible biological names infered from orthology : discoidin, CUB and LCCL domain containing 2 / Q96PD2
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C1.2
Gene start: 58408443
Gene end: 58469727
  
Corresponding Affymetrix probe sets: 10436372 (MoGene1.0st)   1420526_at (Mouse Genome 430 2.0 Array)   1437635_at (Mouse Genome 430 2.0 Array)   1449891_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039915
NCBI entrez gene - 73379     See in Manteia.
MGI - MGI:1920629
RefSeq - XM_011246022
RefSeq - NM_001356484
RefSeq - NM_028523
RefSeq - XM_006522622
RefSeq - XM_006522624
RefSeq Peptide - NP_001343413
RefSeq Peptide - NP_082799
swissprot - Q91ZV3
Ensembl - ENSMUSG00000035107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcbld2ENSDARG00000062177Danio rerio
 DCBLD2ENSGALG00000015258Gallus gallus
 DCBLD2ENSG00000057019Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657918
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119618
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG0000001989117
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG0000002581016
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG0000002596916
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG0000003448813
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG0000003060512
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG0000003193610
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG000000312099
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG000000036177
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG000000312935


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR004043  LCCL domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036609  LCCL domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0042060 wound healing IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0011134 decreased lung endothelial cell migration "reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [MGI:csmith]
Show

Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0011140 decreased lung endothelial cell proliferation "reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0013023 decreased Ly6C high monocyte number "decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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