ENSG00000140545


Homo sapiens

Features
Gene ID: ENSG00000140545
  
Biological name :MFGE8
  
Synonyms : MFGE8 / milk fat globule-EGF factor 8 protein / Q08431
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q26.1
Gene start: 88898683
Gene end: 88913411
  
Corresponding Affymetrix probe sets: 1558960_a_at (Human Genome U133 Plus 2.0 Array)   210605_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456281
Ensembl peptide - ENSP00000452926
Ensembl peptide - ENSP00000478952
Ensembl peptide - ENSP00000268150
Ensembl peptide - ENSP00000268151
Ensembl peptide - ENSP00000444332
Ensembl peptide - ENSP00000452734
NCBI entrez gene - 4240     See in Manteia.
OMIM - 602281
RefSeq - XM_017022206
RefSeq - NM_001114614
RefSeq - NM_001310319
RefSeq - NM_001310320
RefSeq - NM_001310321
RefSeq - NM_005928
RefSeq Peptide - NP_005919
RefSeq Peptide - NP_001108086
RefSeq Peptide - NP_001297248
RefSeq Peptide - NP_001297249
RefSeq Peptide - NP_001297250
swissprot - Q08431
swissprot - F5GZN3
swissprot - X6R3G6
swissprot - A0A087WUV5
swissprot - H0YKB5
swissprot - H0YKS8
Ensembl - ENSG00000140545
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MFGE8ENSGALG00000006702Gallus gallus
 Mfge8ENSMUSG00000030605Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDIL3 / O43854 / EGF like repeats and discoidin domains 3ENSG0000016417652
F5 / P12259 / coagulation factor VENSG0000019873440
F8 / P00451 / coagulation factor VIIIENSG0000018501035
NRP2 / O60462 / neuropilin 2ENSG0000011825732
NRP1 / O14786 / neuropilin 1ENSG0000009925029
DCBLD2 / Q96PD2 / discoidin, CUB and LCCL domain containing 2ENSG0000005701925
DCBLD1 / Q8N8Z6 / discoidin, CUB and LCCL domain containing 1ENSG0000016446519
RS1 / O15537 / retinoschisin 1ENSG0000010210414
HEPH / Q9BQS7 / hephaestinENSG000000894727
HEPHL1 / Q6MZM0 / hephaestin like 1ENSG000001813336
CP / P00450 / ceruloplasminENSG000000474574


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000742  EGF-like domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR027060  Lactadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006910 phagocytosis, recognition IEA
 biological_processGO:0006911 phagocytosis, engulfment IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140545 MFGE8 / Q08431 / milk fat globule-EGF factor 8 protein  / -






 

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