ENSDARG00000019371


Danio rerio

Features
Gene ID: ENSDARG00000019371
  
Biological name :flt1
  
Synonyms : flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  
Possible biological names infered from orthology : fms related tyrosine kinase 1 / P17948
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 21750810
Gene end: 21808819
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000106307
Ensembl peptide - ENSDARP00000002466
NCBI entrez gene - 544667     See in Manteia.
RefSeq - NM_001014829
RefSeq - NM_001257153
RefSeq Peptide - NP_001014829
RefSeq Peptide - NP_001244082
swissprot - B3DKP1
swissprot - F1QBD0
ZFIN ID - ZDB-GENE-050407-1
Ensembl - ENSDARG00000019371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FLT1ENSGALG00000017091Gallus gallus
 FLT1ENSG00000102755Homo sapiens
 Flt1ENSMUSG00000029648Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445339
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732139
kdrl / kinase insert domain receptor likeENSDARG0000010521538
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089723
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049423
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298622
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613322
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331721
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362421
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811518
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102718
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478218
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910517
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530517
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119016
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009135  Vascular endothelial growth factor receptor 1 (VEGFR1)
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0060841 venous blood vessel development IMP
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased contractility , abnormal
cardiac ventricle non-contractile , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta endothelial cell increased amount , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type CNS neuron (sensu Vertebrata) , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein endothelial cell increased amount , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein vascular sprouts increased amount , abnormal
intersegmental vein endothelial cell increased amount , abnormal
intersegmental vein increased amount , abnormal
intersegmental vein dorsal region branchiness , exacerbated
intersegmental vein vascular sprouts increased amount , exacerbated
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 ZFA:0001061 intersegmental artery intersegmental artery increased branchiness , abnormal
intersegmental artery branched , abnormal
intersegmental artery endothelial cell increased amount , abnormal
intersegmental artery vascular sprouts increased amount , abnormal
intersegmental artery decreased amount , abnormal
intersegmental artery branchiness , ameliorated
intersegmental artery increased branchiness , exacerbated
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 ZFA:0001285 intersegmental vessel intersegmental vessel endothelial tip cell increased width , abnormal
intersegmental vessel disorganized , abnormal
intersegmental vessel dorsal region increased branchiness , abnormal
intersegmental vessel vascular sprouts increased amount , abnormal
intersegmental vessel vascular sprouts displaced to neural tube , abnormal
intersegmental vessel dorsal region branchiness , exacerbated
intersegmental vessel vascular sprouts increased amount , exacerbated
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 ZFA:0005024 trunk vasculature trunk vasculature dorsal region has extra parts of type blood vessel , abnormal
trunk vasculature dorsal region has extra parts of type vascular sprouts , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel endothelial cell increased amount , abnormal
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 ZFA:0005559 vascular sprouts vascular sprouts has extra parts of type endothelial tip cell , abnormal
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 ZFA:0005604 angiogenic sprout angiogenic sprout increased amount , abnormal
angiogenic sprout branchiness , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019371 flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*  / complex / reaction
 ENSDARG00000090997 vegfba / vascular endothelial growth factor Ba / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*  / reaction / complex
 ENSDARG00000092480 vegfbb / vascular endothelial growth factor Bb / VEGFB* / P49765* / P49766* / vascular endothelial growth factor B*  / complex / reaction
 ENSDARG00000076767 pgfb / placental growth factor b / PGF* / P49764* / P49763* / placental growth factor*  / reaction / complex
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / complex / reaction






 

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