ENSDARG00000102986


Danio rerio

Features
Gene ID: ENSDARG00000102986
  
Biological name :csf1ra
  
Synonyms : colony stimulating factor 1 receptor, a / csf1ra
  
Possible biological names infered from orthology : colony stimulating factor 1 receptor / CSF1R / Macrophage colony-stimulating factor 1 receptor / P07333 / P09581
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 3143337
Gene end: 3180947
  
Corresponding Affymetrix probe sets: Dr.10333.1.S1_at (Zebrafish Array)   NM_131672_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000156167
Ensembl peptide - ENSDARP00000134935
Ensembl peptide - ENSDARP00000148187
NCBI entrez gene - 64274     See in Manteia.
RefSeq - NM_131672
RefSeq - XM_021481056
RefSeq - XM_021481057
RefSeq Peptide - NP_571747
swissprot - A0A0R4IML5
ZFIN ID - ZDB-GENE-001205-1
Ensembl - ENSDARG00000102986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CSF1RENSGALG00000005725Gallus gallus
 CSF1RENSG00000182578Homo sapiens
 Csf1rENSMUSG00000024621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362443
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331737
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613337
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089732
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049430
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732129
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937129
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445328
kdrl / kinase insert domain receptor likeENSDARG0000010521528
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850325
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478223
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811523
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910522
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102722
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119021
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR030658  Macrophage colony-stimulating factor 1 receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019955 cytokine binding IEA


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain lacks all parts of type microglial cell , abnormal
brain immune response in brain or nervous system decreased efficacy , abnormal
brain macrophage decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium macrophage decreased amount , abnormal
Show

 ZFA:0000075 spinal cord spinal cord protruding into central canal , abnormal
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 ZFA:0000094 blood island blood island macrophage decreased amount , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle macrophage decreased amount , abnormal
fourth ventricle monocyte decreased amount , abnormal
Show

 ZFA:0000123 liver liver macrophage decreased amount , abnormal
Show

 ZFA:0000128 midbrain midbrain macrophage decreased amount , abnormal
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 ZFA:0000152 retina retina neurogenesis decreased process quality , abnormal
retina neuron differentiation delayed , abnormal
retina lacks all parts of type microglial cell , abnormal
retina undifferentiated , abnormal
retina proliferative , abnormal
retina neuron differentiation decreased process quality , abnormal
Show

 ZFA:0000180 caudal vein caudal vein mislocalised , abnormal
Show

 ZFA:0000295 trigeminal ganglion trigeminal ganglion degenerate , abnormal
trigeminal ganglion axon degenerate , abnormal
Show

 ZFA:0000436 spleen spleen macrophage decreased amount , abnormal
Show

 ZFA:0000519 hemal arch hemal arch osteoclast decreased amount , abnormal
Show

 ZFA:0000938 central canal central canal decreased diameter , abnormal
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 ZFA:0001058 caudal fin caudal fin macrophage decreased amount , abnormal
Show

 ZFA:0001066 neural arch neural arch osteoclast decreased amount , abnormal
neural arch increased area , abnormal
neural arch decreased angle to vertebra , abnormal
Show

 ZFA:0001094 whole organism whole organism spotted , abnormal
whole organism has fewer parts of type melanocyte , abnormal
whole organism has fewer parts of type xanthophore , abnormal
whole organism desaturated yellow , abnormal
whole organism decreased life span , abnormal
whole organism decreased size , abnormal
whole organism decreased pigmentation , abnormal
whole organism lacks all parts of type xanthophore , abnormal
Show

 ZFA:0001114 head head has fewer parts of type xanthophore , abnormal
head xanthophore irregular spatial pattern , abnormal
Show

 ZFA:0001115 trunk trunk lacks all parts of type xanthophore , abnormal
trunk melanophore stripe disorganized , abnormal
trunk ventro-lateral region has fewer parts of type xanthophore , abnormal
trunk melanophore stripe malformed , abnormal
trunk melanophore stripe has fewer parts of type melanocyte , abnormal
trunk melanocyte mislocalised , abnormal
trunk iridophore mislocalised , abnormal
trunk dermis lacks all parts of type xanthophore , abnormal
trunk dermis has fewer parts of type melanocyte , abnormal
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 ZFA:0001136 hypodermis hypodermis melanocyte decreased amount , abnormal
hypodermis xanthophore absent , abnormal
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 ZFA:0001162 anal fin anal fin spotted , abnormal
anal fin has fewer parts of type melanophore stripe , abnormal
anal fin melanophore stripe patchy , abnormal
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 ZFA:0001189 vertebra vertebra decreased size , abnormal
vertebra morphology , abnormal
vertebra increased volume , abnormal
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 ZFA:0001291 facial ganglion facial ganglion degenerate , abnormal
facial ganglion axon degenerate , abnormal
Show

 ZFA:0001301 glossopharyngeal ganglion glossopharyngeal ganglion degenerate , abnormal
glossopharyngeal ganglion axon degenerate , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe absent , abnormal
melanophore stripe low saturation , abnormal
melanophore stripe patchy , abnormal
melanophore stripe irregular spatial pattern , abnormal
melanophore stripe spotted , abnormal
Show

 ZFA:0007067 vagal ganglion vagal ganglion degenerate , abnormal
vagal ganglion axon degenerate , abnormal
Show

 ZFA:0009077 microglial cell microglial cell decreased amount , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
pigment cell irregular spatial pattern , abnormal
Show

 ZFA:0009091 melanocyte melanocyte irregular spatial pattern , abnormal
melanocyte quality , abnormal
melanocyte decreased amount , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased amount , abnormal
macrophage decreased speed , abnormal
macrophage spherical , abnormal
Show

 ZFA:0009198 xanthophore xanthophore spatial pattern , abnormal
xanthophore decreased amount , abnormal
xanthophore area density , abnormal
xanthophore quality , abnormal
xanthophore absent , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell undifferentiated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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