ENSDARG00000070494


Danio rerio

Features
Gene ID: ENSDARG00000070494
  
Biological name :pdgfra
  
Synonyms : pdgfra / platelet-derived growth factor receptor, alpha polypeptide
  
Possible biological names infered from orthology : Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234 / P26618 / platelet derived growth factor receptor alpha
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 22435180
Gene end: 22476255
  
Corresponding Affymetrix probe sets: Dr.12.1.S1_at (Zebrafish Array)   Dr.12.1.S2_at (Zebrafish Array)   NM_131459_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000094286
Ensembl peptide - ENSDARP00000132650
NCBI entrez gene - 386856     See in Manteia.
RefSeq - NM_131459
RefSeq Peptide - NP_571534
swissprot - F1QNY7
swissprot - A4JYD9
ZFIN ID - ZDB-GENE-990415-208
Ensembl - ENSDARG00000070494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDGFRAENSGALG00000013929Gallus gallus
 P16234ENSG00000134853Homo sapiens
 P26618ENSMUSG00000029231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089729
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613322
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331722
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362421
kdrl / kinase insert domain receptor likeENSDARG0000010521520
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298620
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937120
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732120
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445320
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850317
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811516
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530516
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478215
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102715
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910515
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027290  Platelet-derived growth factor receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035790 platelet-derived growth factor receptor-alpha signaling pathway IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005018 platelet-derived growth factor alpha-receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
brain hydrocephalic , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle bifurcated , abnormal
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 ZFA:0000013 cranial ganglion cranial ganglion absent , abnormal
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 ZFA:0000028 heart primordium heart primordium separated from heart primordium , abnormal
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 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
anatomical structure absent , abnormal
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 ZFA:0000045 neural crest neural crest separated from dorsal aorta , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
heart collapsed , abnormal
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 ZFA:0000471 atrium atrium increased size , abnormal
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 ZFA:0000590 oral region oral region neural crest cell migration process quality , abnormal
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 ZFA:0000737 cranium cranium hemorrhagic , abnormal
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 ZFA:0001078 thymus thymus decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism medial region absent , abnormal
whole organism anterior-posterior axis decreased size , abnormal
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 ZFA:0001202 optic cup optic cup absent , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage hypoplastic , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium hypoplastic , abnormal
splanchnocranium morphology , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature perforate , abnormal
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 ZFA:0001320 endocardium endocardium cardioblast cell midline fusion process quality , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula broken , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage shape , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage split , abnormal
ethmoid cartilage perforate , abnormal
ethmoid cartilage unfused from ethmoid cartilage , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage shape , abnormal
hyosymplectic cartilage hypoplastic , abnormal
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 ZFA:0001423 parachordal cartilage parachordal cartilage decreased size , abnormal
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 ZFA:0001424 chondrocranium chondrocranium decreased length , abnormal
chondrocranium decreased width , abnormal
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 ZFA:0001461 chondrocranium cartilage chondrocranium cartilage neural crest cell migration decreased occurrence , abnormal
chondrocranium cartilage cranial neural crest cell decondensed , abnormal
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 ZFA:0001580 neurocranium neurocranium decreased length , abnormal
neurocranium lacks all parts of type neurocranial trabecula , abnormal
neurocranium lacks all parts of type ethmoid cartilage , abnormal
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 ZFA:0001718 presumptive atrium heart tube presumptive atrium heart tube increased width , abnormal
presumptive atrium heart tube distended , abnormal
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 ZFA:0001719 presumptive cardiac ventricle heart tube presumptive cardiac ventricle heart tube decreased size , abnormal
presumptive cardiac ventricle heart tube increased width , abnormal
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 ZFA:0005041 anterior lateral plate mesoderm anterior lateral plate mesoderm spatial pattern , abnormal
anterior lateral plate mesoderm far from anterior lateral plate mesoderm , abnormal
anterior lateral plate mesoderm separated from anterior lateral plate mesoderm , abnormal
anterior lateral plate mesoderm absent , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle morphology , abnormal
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 ZFA:0005280 cardiac muscle cardiac muscle morphology , abnormal
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 ZFA:0005509 palate palate decreased length , abnormal
palate skeletal tissue absent , abnormal
palate cleft , abnormal
palate hypoplastic , abnormal
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 ZFA:0007006 lip lip decreased size , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
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 ZFA:0009165 neural crest cell neural crest cell apoptotic , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell spatial pattern , abnormal
cardiac muscle cell decreased speed , abnormal
cardiac muscle cell decreased velocity , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028699 crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like / P46109* / P47941* / Crk-like protein * / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / complex
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / complex






 

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