ENSDARG00000011027


Danio rerio

Features
Gene ID: ENSDARG00000011027
  
Biological name :fgfr1a
  
Synonyms : fgfr1a / fibroblast growth factor receptor 1a / Q90Z00
  
Possible biological names infered from orthology : FGFR1 / fibroblast growth factor receptor 1 / P11362 / P16092
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 51430597
Gene end: 51524453
  
Corresponding Affymetrix probe sets: Dr.12614.1.S1_a_at (Zebrafish Array)   Dr.2685.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000116533
Ensembl peptide - ENSDARP00000131679
Ensembl peptide - ENSDARP00000013742
Ensembl peptide - ENSDARP00000110910
Ensembl peptide - ENSDARP00000115638
NCBI entrez gene - 30705     See in Manteia.
RefSeq - NM_001309400
RefSeq Peptide - NP_001296329
swissprot - A0A0R4IEQ9
swissprot - F1QWQ8
swissprot - Q90Z00
ZFIN ID - ZDB-GENE-980526-255
Ensembl - ENSDARG00000011027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGFR1ENSGALG00000039786Gallus gallus
 FGFR1ENSG00000077782Homo sapiens
 Fgfr1ENSMUSG00000031565Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119070
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811563
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478259
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910557
kdrl / kinase insert domain receptor likeENSDARG0000010521529
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445329
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732129
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937128
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613327
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089727
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049427
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298627
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530526
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331726
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362425
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016248  Fibroblast growth factor receptor family
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028174  Fibroblast growth factor receptor 1, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010863 positive regulation of phospholipase C activity ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021628 olfactory nerve formation IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0036342 post-anal tail morphogenesis IGI
 biological_processGO:0042664 negative regulation of endodermal cell fate specification IGI
 biological_processGO:0043406 positive regulation of MAP kinase activity ISS
 biological_processGO:0043589 skin morphogenesis IMP
 biological_processGO:0045471 response to ethanol IDA
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0048916 posterior lateral line development IMP
 biological_processGO:0060249 anatomical structure homeostasis IMP
 biological_processGO:0071699 olfactory placode morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005007 fibroblast growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding ISS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR1c ligand binding and activation
FGFR1c and Klotho ligand binding and activation
Signal transduction by L1
Phospholipase C-mediated cascade: FGFR1
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
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 ZFA:0000249 cranial nerve I cranial nerve I axon mislocalised , abnormal
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 ZFA:0000277 scale scale increased size , abnormal
scale patchy , abnormal
scale decreased amount , abnormal
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 ZFA:0000554 olfactory epithelium olfactory epithelium morphology , abnormal
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 ZFA:0001115 trunk trunk shortened , abnormal
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 ZFA:0001117 post-vent region post-vent region malformed , abnormal
post-vent region has fewer parts of type mesoderm , abnormal
post-vent region shortened , abnormal
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 ZFA:0005661 olfactory bulb glomerulus olfactory bulb glomerulus morphology , abnormal
olfactory bulb glomerulus malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000097299 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000076895 flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *  / complex / reaction
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / complex / reaction
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000075597 flrt1b / fibronectin leucine rich transmembrane protein 1b / FLRT1* / Q6RKD8* / Q9NZU1* / fibronectin leucine rich transmembrane protein 1* / Leucine-rich repeat transmembrane protein FLRT1 *  / reaction / complex
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000079355 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction






 

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