ENSMUSG00000031565


Mus musculus

Features
Gene ID: ENSMUSG00000031565
  
Biological name :Fgfr1
  
Synonyms : Fgfr1 / Fibroblast growth factor receptor 1 / P16092
  
Possible biological names infered from orthology : P11362
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 25513654
Gene end: 25575718
  
Corresponding Affymetrix probe sets: 10570982 (MoGene1.0st)   1424050_s_at (Mouse Genome 430 2.0 Array)   1425911_a_at (Mouse Genome 430 2.0 Array)   1436551_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131343
Ensembl peptide - ENSMUSP00000148135
Ensembl peptide - ENSMUSP00000148032
Ensembl peptide - ENSMUSP00000147898
Ensembl peptide - ENSMUSP00000137515
Ensembl peptide - ENSMUSP00000136640
Ensembl peptide - ENSMUSP00000081041
Ensembl peptide - ENSMUSP00000113855
Ensembl peptide - ENSMUSP00000113909
Ensembl peptide - ENSMUSP00000116564
Ensembl peptide - ENSMUSP00000117884
NCBI entrez gene - 14182     See in Manteia.
MGI - MGI:95522
RefSeq - XM_011242121
RefSeq - XM_011242120
RefSeq - XM_006509013
RefSeq - XM_006509012
RefSeq - XM_006509010
RefSeq - NM_001079908
RefSeq - NM_010206
RefSeq - NM_001079909
RefSeq Peptide - NP_001073377
RefSeq Peptide - NP_001073378
RefSeq Peptide - NP_034336
swissprot - D3YW77
swissprot - P16092
swissprot - Q8CIM9
swissprot - J3QN85
swissprot - A0A1B0GSD9
swissprot - A0A1B0GSQ7
swissprot - D3Z4V6
swissprot - A0A1B0GSZ6
Ensembl - ENSMUSG00000031565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgfr1aENSDARG00000011027Danio rerio
 fgfr1bENSDARG00000011190Danio rerio
 FGFR1ENSGALG00000039786Gallus gallus
 FGFR1ENSG00000077782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084972
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425262
Fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSMUSG0000000532054
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964831
Kdr / kinase insert domain receptor / P35968*ENSMUSG0000006296031
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567229
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923128
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011028
Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*ENSMUSG0000002035728
Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*ENSMUSG0000002462028
Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*ENSMUSG0000002462127
Flt3 / fms related tyrosine kinase 3 / P36888*ENSMUSG0000004281725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR016248  Fibroblast growth factor receptor family
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028174  Fibroblast growth factor receptor 1, catalytic domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001657 ureteric bud development IGI
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001759 organ induction IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002062 chondrocyte differentiation IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007435 salivary gland morphogenesis IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010863 positive regulation of phospholipase C activity ISS
 biological_processGO:0010966 regulation of phosphate transport IGI
 biological_processGO:0010976 positive regulation of neuron projection development IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0021769 orbitofrontal cortex development IMP
 biological_processGO:0021847 ventricular zone neuroblast division IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0042473 outer ear morphogenesis IMP
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity ISS
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043583 ear development IMP
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048339 paraxial mesoderm development IGI
 biological_processGO:0048378 regulation of lateral mesodermal cell fate specification IGI
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0048762 mesenchymal cell differentiation IGI
 biological_processGO:0051174 regulation of phosphorus metabolic process IGI
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0060117 auditory receptor cell development IMP
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IMP
 biological_processGO:0060484 lung-associated mesenchyme development IGI
 biological_processGO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0070640 vitamin D3 metabolic process IGI
 biological_processGO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0090272 negative regulation of fibroblast growth factor production IGI
 biological_processGO:1903465 positive regulation of mitotic cell cycle DNA replication IDA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
 biological_processGO:2000830 positive regulation of parathyroid hormone secretion IGI
 biological_processGO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005007 fibroblast growth factor-activated receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0090722 receptor-receptor interaction ISO


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR1c ligand binding and activation
FGFR1c and Klotho ligand binding and activation
Signal transduction by L1
Phospholipase C-mediated cascade: FGFR1
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

 MP:0000022 abnormal ear shape "malformation of the pattern of the external ear" [J:65038]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1Eask/Fgfr1+
Genetic Background: BALB/cByJ-Fgfr1Eask/GrsrJ

 MP:0000023 abnormal ear distance/ position "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1Eask/Fgfr1+
Genetic Background: BALB/cByJ-Fgfr1Eask/GrsrJ

 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1Eask/Fgfr1+
Genetic Background: BALB/cByJ-Fgfr1Eask/GrsrJ

 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dbmc3BTBR/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000040 absent middle ear ossicles "missing small bones of the tympanic cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Dbmc3BTBR/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbmc3BTBR/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0000081 premature suture closure "early fusion of the bones of the skull" [J:26513]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Fgfr1tm5.1Sor/Fgfr1tm5.1Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: 129S4.Cg-Fgfr1tm5.1Sor H2afvTg(Wnt1-cre)11Rth

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Dbmc3BTBR/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1.1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

Allelic Composition: Fgfr1tm5.1Sor/Fgfr1tm9.1Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: 129S4.Cg-Fgfr1tm5.1Sor Fgfr1tm9.1Sor H2afvTg(Wnt1-cre)11Rth

Allelic Composition: Fgfr1tm5.1Sor/Fgfr1tm10.1Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: 129S4.Cg-Fgfr1tm5.1Sor Fgfr1tm10.1Sor H2afvTg(Wnt1-cre)11Rth

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1Hspy
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxb1tm1Pgr/Foxb1tm1Pgr
Genetic Background: B6.129-Foxb1tm1Pgr

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1.1Jpa,Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Gja1tm1.1Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Cebpatm2Btp/Cebpatm2Btp
Genetic Background: B6.129P2-Cebpatm2Btp

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbmc3BTBR/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000865 absent vermis "missing narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001063 abnormal trochlear nerve morphology "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Fgfr1tm1Swnr/Fgfr1tm1Swnr,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcl13tm1Cys/Cxcl13tm1Cys
Genetic Background: B6.129X1-Cxcl13tm1Cys

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Cxcl13tm1Cys/Cxcl13tm1Cys
Genetic Background: B6.129X1-Cxcl13tm1Cys

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.1Jrt/Fgfr1tm3.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.1Jrt/Fgfr1tm3.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm4.1Sor/Fgfr1tm4.1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Fgfr1tm1Swnr/Fgfr1tm1Swnr,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4.1Sor/Fgfr1tm4.1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1.1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4.1Jrt/Fgfr1tm4.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5.1Jrt/Fgfr1tm5.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Fgfr1Eask/Fgfr1+
Genetic Background: BALB/cByJ-Fgfr1Eask/GrsrJ

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Neil1tm1Rsld/Neil1+
Genetic Background: either: B6.129S1-Neil1tm1Rsld or (involves: 129S1/Sv * C57BL/6)

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0003308 abnormal cochlear sensory epithelium 
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Neil1tm1Rsld/Neil1+
Genetic Background: either: B6.129S1-Neil1tm1Rsld or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0003854 abnormal forelimb stylopod morphology 
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0003855 abnormal forelimb zeugopod morphology 
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp11cm2Anu/Y
Genetic Background: C57BL/6JAnu-Atp11cm2Anu/AnuApb

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm3.1Sor/Fgfr1tm3.1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Fgfr1Hspy/Fgfr1Hspy
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1+,Spry2tm1.1Mrt/Spry2tm1.1Mrt
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0004301 absent supporting cells "absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004411 decreased endocochlear potential "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0004415 abnormal cochlear nerve compound action potential "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004573 absent limb buds "missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004574 broad limb buds "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004576 abnormal foot plate morphology "any structural anomaly of the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004589 abnormal cochlear hair cell development "atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0004648 decreased thoracic vertebrae number "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Fgfr1tm8.1Sor/Fgfr1tm8.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm8.1Sor

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1.1Jpa,Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: B6J.129S6(Cg)-Fgfr1tm2.1Cxd

 MP:0005274 abnormal viscerocranium morphology "anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: B6J.129S6(Cg)-Fgfr1tm2.1Cxd

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1+,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: FVB/N

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster

 MP:0006281 abnormal tail development "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006338 abnormal second branchial arch morphology "anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm3Jrt/Fgfr1tm3Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.1Jrt/Fgfr1tm3.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008023 abnormal styloid process morphology "any structural abnormality in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6.1Jrt/Fgfr1tm6.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008219 abnormal dorsal telencephalic commissure morphology "any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure" [PMID:16715082]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0008381 absent gonial bone "absence of the investing bone that normally lies on the surface of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
Show

Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified

 MP:0008854 bleb "presence of a blister-like, nearly hemispherical structure formed during embryonic development filled with air, serous fluid or blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0008863 craniofacial asymmetry "head or facial features that lack mirrored identity on either side of the median plane" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Fgfr1tm1Swnr/Fgfr1tm1Swnr,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T7J/T+
Genetic Background: C57BL/6J-T7J

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009039 absent inferior colliculus "absence of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Fgfr1tm1Jpa/Fgfr1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0009845 abnormal neural crest cell morphology "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009914 abnormal hyoid bone lesser horn morphology "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010326 malleus hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0010678 abnormal skin adnexa morphology "any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Fgfr1tm1Swnr/Fgfr1tm1Swnr,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010979 small ureteric bud "reduced size of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0010980 ectopic ureteric bud "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0010982 abnormal ureteric bud elongation "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1.1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1Eask/Fgfr1Eask
Genetic Background: BALB/cByJ-Fgfr1Eask/GrsrJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgfr1tm1Cxd/Fgfr1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

Allelic Composition: Fgfr1tm4Sor/Fgfr1tm4Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Fgfr1tm3Sor/Fgfr1tm3Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Fgfr1tm1.1Upir/Fgfr1tm1.1Upir
Genetic Background: involves: ICR

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1Hspy
Genetic Background: C3HeB/FeJ-Fgfr1Hspy

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm3.1Sor/Fgfr1tm3.1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm3Jrt/Fgfr1tm3Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.1Jrt/Fgfr1tm3.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm4Jrt/Fgfr1tm4Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm4.1Sor/Fgfr1tm4.1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
Show

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm5.2Sor

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011208 small proamniotic cavity "reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011256 abnormal neural fold morphology "any structural anomaly of the elevated margins of the neural groove" [ISBN:0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm5Jrt/Fgfr1tm5Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm3.1Lni/Fgfr2tm3.1Lni,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

 MP:0011387 absent metanephric mesenchyme "absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011485 abnormal urethra urothelium morphology "any structural anomaly of the epithelial lining of the luminal space of the urethra" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011696 absent mast cells "any structural anomaly of a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation; progenitors leave bone marrow and mature in connective and mucosal tissue; mature mast cells are found in all tissues, except the bloodstream." [CL:0000097]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Fgfr1tm6Jrt/Fgfr1tm6Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm10.1Sor/Fgfr1tm10.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm10.1Sor

 MP:0011772 genital tubercle hypoplasia "underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Fgfr1Eask/Fgfr1+
Genetic Background: BALB/cByJ-Fgfr1Eask/GrsrJ

 MP:0012085 midface hypoplasia "underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: D2.129S6(Cg)-Fgfr1tm2.1Cxd

 MP:0012131 small visceral yolk sac "reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [MGI:anna]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm3Jrt/Fgfr1tm3Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm3.1Jrt/Fgfr1tm3.1Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0012274 increased axial mesoderm size "greater than average size of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0012740 abnormal posterior primitive streak morphology "any structural anomaly of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm" [MGI:anna]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0013164 abnormal forelimb bud morphology "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
Show

Allelic Composition: Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0013268 second pharyngeal arch hypoplasia "underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number" [MGI:anna]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0014051 abnormal maxillary-premaxillary suture morphology "any structural anomaly of the line of union of the two portions of the maxilla (pre- and postmaxilla)" [ISBN:0683400088]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: D2.129S6(Cg)-Fgfr1tm2.1Cxd

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: B6J.129S6(Cg)-Fgfr1tm2.1Cxd

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0020516 abnormal visceral yolk sac mesenchyme morphology "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0030084 tympanic ring hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the bony ring at the ear canal to which the tympanic membrane is attached" [MGI:anna]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0030099 facial asymmetry "an abnormal difference between the left and right sides of the face" [HP:0000324]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0030107 incus hypoplasia "underdevelopment or reduced size, usually due to reduced cell number, of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [MGI:anna]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0030108 abnormal incudostapedial joint morphology "any structural anomaly of the small synovial joint located between the lenticular process on the long crus of the incus and the head of the stapes" [http://medical-dictionary.thefreedictionary.com/incudostapedial+joint]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030119 abnormal retrotympanic process morphology "any structural anomaly of the posterior extension of the squamosal bone that lies just above the incus" [PMID:28566723]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0030124 middle ear ossicle hypoplasia "underdevelopment or reduced size of the three bones of the middle ear, usually due to reduced cell number" [MGI:anna]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0030125 small gonial bone "reduced size of the investing bone that lies on the surface of the malleus" [MGI:anna]
Show

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Fgfr1tm2Jrt/Fgfr1tm2Jrt,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0030128 stapes hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [MGI:anna]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0030160 abnormal auditory bulla morphology "any structural anomaly of the hollow bony structure on the ventral, posterior portion of the skull that encloses parts of the middle and inner ear; in most species, it is formed by the tympanic part of the temporal bone" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030322 styloid process hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna]
Show

Allelic Composition: Fgfr1tm9.1Sor/Fgfr1tm9.1Sor
Genetic Background: 129S4/SvJaeSor-Fgfr1tm9.1Sor

 MP:0030350 premature coronal suture closure "early closure of the coronal suture of the skull" [MGI:anna]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0030354 premature sagittal suture closure "early closure of the sagittal suture of the skull; premature closure of this suture results in a long, narrow, and boat-shaped skull (scaphocephaly)" [https://radiopaedia.org/articles/craniosynostosis]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0030367 premature metopic suture closure "early closure of the metopic suture of the skull; premature closure of this suture compromises the transverse growth of both the frontal bones and can cause a narrow, triangular shaped forehead (trigonocephaly) that is associated with orbital hypotelorism" [http://www.skullbaseinstitute.com/craniosynostosis-craniofacial/trigonocephaly.html, PMID:23960302]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0030394 abnormal incus short process morphology "any structural anomaly of the short limb (crus) of the incus that fits into a depression (fossa incudis) in the epitympanic recess; it is attached to the cavity wall by the posterior incudal ligament" [http://audilab.bmed.mcgill.ca/~daren/3Dear/mid1.html, https://medical-dictionary.thefreedictionary.com/short+limb+of+incus]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030396 abnormal incus long process morphology "any structural anomaly of the long limb (crus) of the incus; at the tip of the long crus there is a small knob, the lenticular process, that articulates with the head of the stapes" [https://medical-dictionary.thefreedictionary.com/long+limb+of+incus]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030398 absent incus lenticular process "missing the ovoid end of the incus that articulates with the head of the stapes; normally, it is attached to the long process by a thin strut or pedicle" [MGI:anna]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030399 abnormal incus body morphology "any structural anomaly of the flat, main part of the incus that articulates with the head of the malleus; two spines, the short and long processes, arise from the lower posterior part of the body and diverge from each other in a right angle" [https://books.google.com/books?isbn=3642369677]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030403 absent stapes head "missing the concave portion of the stapes, located on top of the neck, which articulates with the lenticular process of the long limb of the incus through the incudostapedial joint" [MGI:anna]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030408 abnormal stapes posterior crus morphology "any structural anomaly of the generally longer arching stem of the stapes that projects medially from the neck, forming the posterior border of the bone, and joins the flat, disc-like base" [http://www.anatomyexpert.com/app/structure/746/1925/]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030411 small round window "reduced size of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [MGI:anna]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030412 absent round window "absence of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [MGI:anna]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030419 excessive cerumen "excess buildup of cerumen, a yellowish waxy substance (earwax), in the external auditory canal" [HP:0030789]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0030434 premature maxillary-premaxillary suture closure "early closure of the maxillary-premaxillary suture, the line of union of the two portions of the maxilla (pre- and postmaxilla)" [MGI:anna]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: D2.129S6(Cg)-Fgfr1tm2.1Cxd

 MP:0030438 increased osteoblast proliferation "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
Show

Allelic Composition: Fgfr1tm2.1Cxd/Fgfr1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0030537 abnormal notochordal process morphology "any structural anomaly of the midline cellular cord formed from the migration of mesenchymal cells from the primitive knot; the notochordal process is a mesodermal hollow tube structure that grows cranially between the ectoderm and the endoderm until it reaches the prechordal plate" [http://howmed.net/anatomy/embryology/3rd-week-of-development-trilaminar-germ-disc/, https://medical-dictionary.thefreedictionary.com/head+process, UBERON:0006268]
Show

Allelic Composition: Fgfr1tm1Jrt/Fgfr1tm1Jrt
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000051379 Flrt3 / Q8BGT1 / Leucine-rich repeat transmembrane protein FLRT3 / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*  / reaction / complex
 ENSMUSG00000047414 Flrt2 / Q8BLU0 / Leucine-rich repeat transmembrane protein FLRT2 / O43155* / fibronectin leucine rich transmembrane protein 2*  / complex / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000047787 Flrt1 / Q6RKD8 / Leucine-rich repeat transmembrane protein FLRT1 / Q9NZU1* / fibronectin leucine rich transmembrane protein 1*  / complex / reaction
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr