ENSMUSG00000047414


Mus musculus

Features
Gene ID: ENSMUSG00000047414
  
Biological name :Flrt2
  
Synonyms : Flrt2 / Leucine-rich repeat transmembrane protein FLRT2 / Q8BLU0
  
Possible biological names infered from orthology : fibronectin leucine rich transmembrane protein 2 / O43155
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 95692226
Gene end: 95785215
  
Corresponding Affymetrix probe sets: 10397633 (MoGene1.0st)   1438702_at (Mouse Genome 430 2.0 Array)   1455096_at (Mouse Genome 430 2.0 Array)   1456874_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062171
Ensembl peptide - ENSMUSP00000105744
NCBI entrez gene - 399558     See in Manteia.
MGI - MGI:3603594
RefSeq - XM_011244132
RefSeq - NM_201518
RefSeq - XM_006516055
RefSeq Peptide - NP_958926
swissprot - Q8BLU0
Ensembl - ENSMUSG00000047414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flrt2ENSDARG00000079355Danio rerio
 flrt2ENSDARG00000097299Danio rerio
 FLRT2ENSGALG00000010589Gallus gallus
 FLRT2ENSG00000185070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flrt3 / Q8BGT1 / Leucine-rich repeat transmembrane protein FLRT3 / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*ENSMUSG0000005137945
Flrt1 / Q6RKD8 / Leucine-rich repeat transmembrane protein FLRT1 / Q9NZU1* / fibronectin leucine rich transmembrane protein 1*ENSMUSG0000004778742
Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*ENSMUSG0000005067517
Nepn / Q9CQ76 / Nephrocan ENSMUSG0000003862415
Omg / oligodendrocyte myelin glycoprotein / P23515*ENSMUSG0000004961213
Lrg1 / leucine rich alpha-2-glycoprotein 1 / P02750*ENSMUSG0000003709511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0061343 cell adhesion involved in heart morphogenesis IMP
 biological_processGO:0071711 basement membrane organization IMP
 biological_processGO:2001222 regulation of neuron migration IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045499 chemorepellent activity IDA


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai3tm2.2Grid/Snai3tm2.2Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0010640 ventricular myocardium compact layer hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction / complex
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction






 

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