MP:0000005 | increased brown fat amount | "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208] |
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Allelic Composition: Klkl/Klkl,Tnfrsf11btm1Khs/Tnfrsf11b+ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
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MP:0000029 | abnormal malleus morphology | "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000067 | osteopetrosis | "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0000069 | kyphoscoliosis | "kyphosis combined with scoliosis" [MGI:CML, J:66943] |
Show
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0000131 | abnormal long bone epiphysis morphology | "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509] |
Show
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
|
MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
Show
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
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MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0000194 | hypercalcemia | "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: B6.129S-Kltm1Lex
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000217 | abnormal white blood cell count | "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000249 | abnormal blood vessel physiology | "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000285 | abnormal cardiac valve morphology | "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0000379 | reduced hair follicle number | "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
Show
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000462 | abnormal digestive system morphology | "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Fgf23tm1Blan/Fgf23tm1Blan Genetic Background: involves: 129 * C57BL/6
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MP:0000470 | abnormal stomach morphology | "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000521 | abnormal kidney cortex | "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000559 | abnormal femur morphology | "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0000572 | abnormal autopod morphology | "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000767 | abnormal smooth muscle morphology | "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000880 | decreased Purkinje cell number | "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001132 | absent mature ovarian follicles | "failure of ovarian follicle differentiation" [J:35782] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0001191 | abnormal skin condition | "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001218 | thin epidermis | "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl,Tnfrsf11btm1Khs/Tnfrsf11b+ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan Genetic Background: involves: 129S/SvEvBrd * C57BL/6
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: B6.129S-Kltm1Lex
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud Genetic Background: involves: C57BL/6
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
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MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001429 | dehydration | "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0001454 | abnormal cued conditioning behavior | "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0001469 | abnormal contextual conditioning | "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
Show
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Klkl/Klkl,Tnfrsf11btm1Khs/Tnfrsf11b+ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
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MP:0001566 | hyperphosphatemia | "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan Genetic Background: involves: 129S/SvEvBrd * C57BL/6
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: B6.129S-Kltm1Lex
Allelic Composition: Kltm1.1Tel/Kltm1.1Tel,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0001783 | decreased white fat amount | "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0001924 | infertility | "inability to produce live offspring" [J:47225] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001929 | abnormal gametogenesis | "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan Genetic Background: involves: 129S/SvEvBrd * C57BL/6
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Klkl/Klkl,Tnfrsf11btm1Khs/Tnfrsf11b+ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
Allelic Composition: Kltm1Lex/Kltm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Kltm2Yin/Kltm2Yin Genetic Background: involves: 129S/SvEv
Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan Genetic Background: involves: 129S/SvEvBrd * C57BL/6
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0002128 | abnormal blood circulation | "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kltm1.1Tel/Kltm1.1Tel,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR
Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0002314 | abnormal respiratory mechanics | "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0002801 | abnormal long-term recognition memory | "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0002904 | increased circulating parathyroid hormone level | "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Kltm1.1Tel/Kltm1.1Tel,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR
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MP:0002905 | decreased circulating parathyroid hormone level | "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Kltm1.1Tel/Kltm1.1Tel,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR
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MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
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MP:0003014 | abnormal kidney medulla morphology | "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0003109 | short femur | "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl,Tnfrsf11btm1Khs/Tnfrsf11b+ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003120 | abnormal tracheal cartilage | "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0003195 | calcinosis | "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003196 | skin calcification | "pathologic deposition of calcium salts in the skin" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003197 | kidney calcification | "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan Genetic Background: involves: 129S/SvEvBrd * C57BL/6
Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003199 | muscle calcification | "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003205 | testicular atrophy | "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0003409 | decreased width of hypertrophic chondrocyte zone | "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0003644 | thymus atrophy | "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003662 | abnormal proliferative zone | "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0003786 | premature aging | "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm2Yin/Kltm2Yin Genetic Background: involves: 129S/SvEv
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MP:0003795 | abnormal bone structure | |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003924 | herniated diaphragm | "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0003946 | renal necrosis | "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0003985 | renal fibrosis | "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
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MP:0003991 | arteriosclerosis | "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0004163 | abnormal adenophysis morphology | "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004676 | wide ribs | "an increase in the width of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0004754 | abnormal kidney collecting duct | "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0004833 | ovary atrophy | "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004894 | uterus atrophy | "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004982 | abnormal osteoclast morphology | "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
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MP:0004986 | abnormal osteoblast morphology | "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klkl/Klkl,Tnfrsf11btm1Khs/Tnfrsf11b+ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
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MP:0005105 | abnormal middle ear ossicle morphology | "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0005106 | abnormal incus morphology | "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0005159 | azoospermia | "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0005217 | abnormal pancreatic beta cell morphology | "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Kltm2Yin/Kltm2Yin Genetic Background: involves: 129S/SvEv
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MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0005419 | hypoalbuminemia | "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0005441 | hypercalciuria | "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949] |
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Allelic Composition: Kltm1.1Tel/Kltm1.1Tel,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR
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MP:0005534 | decreased body temperature | "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0005586 | decreased tidal volume | "less than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0005665 | increased circulating noradrenaline level | "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0006116 | aortic valve calcification | "pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0006121 | mitral valve calcification | "pathologic deposition of calcium salts in the mitral valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0006133 | arterial calcification | "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0006142 | abnormal sinoatrial node conduction | "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0006325 | impaired hearing | "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0006357 | abnormal circulating mineral level | "anomalous concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0006358 | absent pinna reflex | "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0006396 | decreased long bone epiphyseal plate size | "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0008261 | arrest of male meiosis | "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0008325 | abnormal gonadotroph morphology | "any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008373 | short malleus | "reduced length of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0008374 | abnormal manubrium morphology | "any structural abnormality in the handle of the malleus, which extends downward, inward, and backward from the neck of the malleus and is embedded throughout its length in the tympanic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0008375 | short manubrium | "reduced length of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0008417 | decreased somatotroph cell size | "reduced growth or small size of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [MESH:A06.407.747.608.937, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008436 | decreased somatotroph secretory granule number | "decreased number of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0009125 | decreased brown fat cell lipid droplet size | "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0009172 | small pancreatic islets | "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0009201 | external male genitalia atrophy | "wasting of the external masculine genital organs, due to injury or disease resulting in reduced size" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009212 | vulva atrophy | "wasting of the external feminine genital organs, collectively known as the vulva, due to injury or disease resulting in reduced size" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
Allelic Composition: Kltm2Yin/Kltm2Yin Genetic Background: involves: 129S/SvEv
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MP:0009866 | abnormal aorta wall morphology | "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0010119 | abnormal bone mineral density | "anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0010506 | prolonged RR interval | "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0010522 | aorta calcification | "pathologic deposition of calcium salts in the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0010870 | absent bone trabeculae | "absence of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0010895 | increased lung compliance | "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0010900 | abnormal pulmonary interalveolar septum morphology | "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0010908 | dilated pulmonary alveolar ducts | "expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Klkl/Klkl Genetic Background: involves: C3H/J * C57BL/6J
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MP:0010923 | pulmonary alveolar calcification | "pathologic deposition of calcium salts in the pulmonary alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Gsn/Kif3a+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Klkl/Kl+ Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0011228 | abnormal vitamin D level | "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368] |
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Allelic Composition: Kltm1Yin/Kltm1Yin Genetic Background: Not Specified
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MP:0011360 | kidney cortex hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the outer portion of the kidney, which contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts" [MGI:anna] |
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Allelic Composition: Kltm1.2Tel/Kltm1.2Tel Genetic Background: involves: C57BL/6 * FVB/N
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MP:0011584 | increased alkaline phosphatase activity | "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0012143 | decreased a wave amplitude | "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith] |
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Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud Genetic Background: involves: C57BL/6
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MP:0012144 | decreased b wave amplitude | "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith] |
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Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud Genetic Background: involves: C57BL/6
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MP:0012151 | increased a wave latency | "increase in the time from onset of stimulus to beginning of the a wave" [MGI:csmith] |
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Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud Genetic Background: involves: C57BL/6
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MP:0012153 | increased b wave latency | "increase in the time from onset of stimulus to beginning of the b wave" [MGI:csmith] |
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Allelic Composition: Nrxn1tm5Sud/Nrxn1tm5Sud Genetic Background: involves: C57BL/6
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MP:0012337 | increased vitamin D level | "greater level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0013566 | dilated gastric glands | "stretched or widened aperture of the luminal space of any of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [MGI:Anna] |
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Allelic Composition: Klm1Anu/Klm1Anu Genetic Background: C57BL/6NCrlAnu-Klm1Anu
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MP:0013624 | decreased femur compact bone thickness | "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0030376 | thick zygomatic arch | "increased thickness of the bony arch that, in vertebrates, extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [MGI:anna] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
Allelic Composition: Klecalc2/Klecalc2 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0030405 | small stapes obturator foramen | "reduced size of the central foramen (hole) located between the crura and the footplate of the stapes through which the stapedial artery passes" [MGI:anna] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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MP:0030584 | skin atrophy | "acquired diminution of skin tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Klecalc1/Klecalc1 Genetic Background: involves: C3H/HeH * C57BL/6J
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