ENSMUSG00000051379


Mus musculus

Features
Gene ID: ENSMUSG00000051379
  
Biological name :Flrt3
  
Synonyms : Flrt3 / Leucine-rich repeat transmembrane protein FLRT3 / Q8BGT1
  
Possible biological names infered from orthology : fibronectin leucine rich transmembrane protein 3 / Q9NZU0
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F3
Gene start: 140650914
Gene end: 140671469
  
Corresponding Affymetrix probe sets: 10488147 (MoGene1.0st)   1429310_at (Mouse Genome 430 2.0 Array)   1453102_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053399
Ensembl peptide - ENSMUSP00000105684
NCBI entrez gene - 71436     See in Manteia.
MGI - MGI:1918686
RefSeq - NM_001172160
RefSeq - NM_178382
RefSeq Peptide - NP_001165631
RefSeq Peptide - NP_848469
swissprot - Q8BGT1
Ensembl - ENSMUSG00000051379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flrt3ENSDARG00000076895Danio rerio
 FLRT3ENSGALG00000008716Gallus gallus
 FLRT3ENSG00000125848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flrt1 / Q6RKD8 / Leucine-rich repeat transmembrane protein FLRT1 / Q9NZU1* / fibronectin leucine rich transmembrane protein 1*ENSMUSG0000004778759
Flrt2 / Q8BLU0 / Leucine-rich repeat transmembrane protein FLRT2 / O43155* / fibronectin leucine rich transmembrane protein 2*ENSMUSG0000004741446
Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*ENSMUSG0000005067518
Nepn / Q9CQ76 / Nephrocan ENSMUSG0000003862415
Omg / oligodendrocyte myelin glycoprotein / P23515*ENSMUSG0000004961212
Lrg1 / leucine rich alpha-2-glycoprotein 1 / P02750*ENSMUSG0000003709512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003345 proepicardium cell migration involved in pericardium morphogenesis IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance ISO
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0048678 response to axon injury ISS
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0060322 head development IMP
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules ISO
 biological_processGO:0099560 synaptic membrane adhesion IC
 biological_processGO:1990138 neuron projection extension ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0097060 synaptic membrane ISS
 cellular_componentGO:0099055 integral component of postsynaptic membrane IC
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0045499 chemorepellent activity IDA


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ncor1tm1Anh/Ncor1tm1Anh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * DBA

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncor1tm1Anh/Ncor1tm1Anh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * DBA

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: Flrt3tm2Kln/Flrt3tm3Kln,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Ncor1tm1Anh/Ncor1tm1Anh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
Show

Allelic Composition: Ncor1tm1Anh/Ncor1tm1Anh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ncor1tm1Anh/Ncor1tm1Anh,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0013283 failure of ventral body wall closure "failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the head and tail folds that cause the embryo to curve into the fetal position and is complete except in the region of the connecting stalk (future umbilical cord); if closure fails, ventral body wall defects occur in the thorax, abdomen, and pelvis and involve the heart (ectopia cordis), abdominal viscera (gastroschisis), and/or urogenital organs (bladder or cloacal exstrophy), depending upon the location and size of the abnormality" [http://www.nbdpn.org/current/2008pdf/AMPresentations/EmbryologySadler.pdf, https://www.inkling.com/read/langmans-medical-embryology-thomas-sadler-12th/chapter-7/ch07-clinical-correlates-01, MGI:anna]
Show

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025020 Slit1 / Q80TR4 / Slit homolog 1 protein / O75093* / slit guidance ligand 1*  / complex / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction / complex






 

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