ENSGALG00000008716


Gallus gallus

Features
Gene ID: ENSGALG00000008716
  
Biological name :FLRT3
  
Synonyms : F1NUK7 / FLRT3 / Leucine-rich repeat transmembrane protein FLRT3
  
Possible biological names infered from orthology : fibronectin leucine rich transmembrane protein 3 / Q8BGT1 / Q9NZU0
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 4691489
Gene end: 4693432
  
Corresponding Affymetrix probe sets: Gga.12088.1.S1_at (Chicken Array)   Gga.12088.2.A1_at (Chicken Array)   Gga.12088.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014168
NCBI entrez gene - 428552     See in Manteia.
RefSeq - XM_015283423
swissprot - F1NUK7
Ensembl - ENSGALG00000008716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flrt3ENSDARG00000076895Danio rerio
 FLRT3ENSG00000125848Homo sapiens
 Flrt3ENSMUSG00000051379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLRT2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *ENSGALG0000001058946
Nepn* / Q9CQ76* / Nephrocan *ENSGALG0000001490016
OMG / oligodendrocyte myelin glycoprotein / P23515*ENSGALG0000000559414
LRG1 / leucine rich alpha-2-glycoprotein 1 / P02750*ENSGALG0000002758711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003345 proepicardium cell migration involved in pericardium morphogenesis IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0048678 response to axon injury ISS
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060322 head development IEA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0097060 synaptic membrane ISS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045499 chemorepellent activity IEA


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / reaction / complex
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction






 

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