ENSGALG00000027791


Gallus gallus

Features
Gene ID: ENSGALG00000027791
  
Biological name :FGF23
  
Synonyms : FGF23 / fibroblast growth factor 23
  
Possible biological names infered from orthology : Q9EPC2 / Q9GZV9
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 73192230
Gene end: 73195635
  
Corresponding Affymetrix probe sets: GgaAffx.11083.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000042002
NCBI entrez gene - 428104     See in Manteia.
RefSeq - XM_425663
swissprot - R4GIR0
Ensembl - ENSGALG00000027791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf23ENSDARG00000045854Danio rerio
 FGF23ENSG00000118972Homo sapiens
 Fgf23ENSMUSG00000000182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *ENSGALG0000002837623


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028304  Fibroblast growth factor 23


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010966 regulation of phosphate transport IEA
 biological_processGO:0010980 positive regulation of vitamin D 24-hydroxylase activity IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030643 cellular phosphate ion homeostasis IEA
 biological_processGO:0042369 vitamin D catabolic process IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0055062 phosphate ion homeostasis IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR1c and Klotho ligand binding and activation
FGFR2c ligand binding and activation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction / complex
 ENSGALG00000010960 GALNT3 / polypeptide N-acetylgalactosaminyltransferase 3 / P70419* / Q14435*  / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000010589 FLRT2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / complex / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / reaction / complex
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000008716 FLRT3 / F1NUK7 / Leucine-rich repeat transmembrane protein FLRT3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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