ENSGALG00000004821


Gallus gallus

Features
Gene ID: ENSGALG00000004821
  
Biological name :PTPN11
  
Synonyms : PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11
  
Possible biological names infered from orthology : P35235 / protein tyrosine phosphatase, non-receptor type 11 / Q06124
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 6441766
Gene end: 6463211
  
Corresponding Affymetrix probe sets: Gga.482.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007692
NCBI entrez gene - 395815     See in Manteia.
RefSeq - NM_204968
RefSeq Peptide - NP_990299
swissprot - Q90687
Ensembl - ENSGALG00000004821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn11aENSDARG00000020334Danio rerio
 PTPN11ENSG00000179295Homo sapiens
 P35235ENSMUSG00000043733Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000003501768
PTPN6 / tyrosine-protein phosphatase non-receptor type 6 / P29350* / P29351* / protein tyrosine phosphatase, non-receptor type 6*ENSGALG0000001456156
PTPRN / protein tyrosine phosphatase, receptor type N / Q16849*ENSGALG0000003381122
PTPRN2 / protein tyrosine phosphatase, receptor type N2 / P80560* / Q92932* / protein tyrosine phosphatase, receptor type, N polypeptide 2*ENSGALG0000003005421
PTPN7 / protein tyrosine phosphatase, non-receptor type 7 / P35236* / Q8BUM3* / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA.*ENSGALG0000003609319
PTPN5 / protein tyrosine phosphatase, non-receptor type 5 / P54829* / P54830* / Tyrosine-protein phosphatase non-receptor type 5 *ENSGALG0000000636819
PTPRR* / Q15256* / Q62132* / protein tyrosine phosphatase, receptor type R*ENSGALG000000101489
PTPRR* / Q15256* / Q62132* / protein tyrosine phosphatase, receptor type R*ENSGALG000000408556


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012152  Protein-tyrosine phosphatase, non-receptor type-6, -11
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0021697 cerebellar cortex formation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0032528 microvillus organization IEA
 biological_processGO:0033277 abortive mitotic cell cycle IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0033629 negative regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035265 organ growth IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0036302 atrioventricular canal development IEA
 biological_processGO:0038127 ERBB signaling pathway IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042445 hormone metabolic process IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046825 regulation of protein export from nucleus IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048609 multicellular organismal reproductive process IEA
 biological_processGO:0048806 genitalia development IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0051463 negative regulation of cortisol secretion IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060125 negative regulation of growth hormone secretion IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0061582 intestinal epithelial cell migration IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISS
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
PI3K Cascade
MAPK1 (ERK2) activation
PIP3 activates AKT signaling
Spry regulation of FGF signaling
Signaling by SCF-KIT
GAB1 signalosome
Downstream signal transduction
Tie2 Signaling
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin-20 family signaling
MET activates PTPN11
Regulation of RUNX1 Expression and Activity
Interferon alpha/beta signaling
Regulation of IFNA signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / reaction / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / complex / reaction
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / reaction / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000015062 IFNK* / IFNA6* / IFNA7* / IFNA8* / Ifna9* / Ifnab* / IFNW1* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / Q9P0W0* / IFNA10* / Ifna11* / Ifna12* / IFNA13* / IFNA14* / Ifna15* / IFNA16* / IFNA17* / I...  / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / complex / reaction
 ENSGALG00000030661 STAT2 / signal transducer and activator of transcription 2 / P52630*  / reaction
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / complex / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSGALG00000014716 IL6ST / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex / reaction
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / reaction / complex
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000034188 PAG1 / phosphoprotein membrane anchor with glycosphingolipid microdomains 1 / Q3U1F9* / Q9NWQ8* / phosphoprotein associated with glycosphingolipid microdomains 1*  / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSGALG00000010273 P48463 / PPP2CB / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein pho...  / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / complex / reaction
 ENSGALG00000006462 PPP2CA / protein phosphatase 2 catalytic subunit alpha / P63330* / P67775* / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform *  / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000010915 IL6 / Q90YI0 / Interleukin-6 / P05231* / P08505*  / complex / reaction
 ENSGALG00000016906 SPRY2 / protein sprouty homolog 2 / O43597* / Q9QXV8* / sprouty RTK signaling antagonist 2*  / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / reaction / complex
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000004221 Q80XZ4* / Q8N6P7* / IL22RA1* / interleukin 22 receptor subunit alpha 1*  / reaction / complex
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex
 ENSGALG00000008666 CTLA4 / cytotoxic T-lymphocyte associated protein 4 / P16410*  / reaction / complex
 ENSGALG00000013929 PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*  / reaction / complex
 ENSGALG00000016022 RUNX1 / runt related transcription factor 1 / Q01196*  / reaction / complex
 ENSGALG00000009904 IL22 / interleukin 22 / Q9JJY8* / Q9JJY9* / Iltifb* / Q9GZX6* / Interleukin-22b *  / complex / reaction
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / reaction / complex
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / reaction / complex
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / reaction / complex






 

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