ENSGALG00000003716


Gallus gallus

Features
Gene ID: ENSGALG00000003716
  
Biological name :GDNF
  
Synonyms : GDNF / glial cell derived neurotrophic factor
  
Possible biological names infered from orthology : Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905 / P48540
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 11726943
Gene end: 11742980
  
Corresponding Affymetrix probe sets: Gga.303.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005887
NCBI entrez gene - 395569     See in Manteia.
RefSeq - XM_004937198
RefSeq - XM_425018
RefSeq - XM_015277531
RefSeq - XM_015277532
swissprot - F1NPM2
Ensembl - ENSGALG00000003716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdnfaENSDARG00000039959Danio rerio
 gdnfbENSDARG00000103764Danio rerio
 GDNFENSG00000168621Homo sapiens
 GdnfENSMUSG00000022144Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRTN / neurturin / P97463* / Q99748*ENSGALG0000002164724
ARTN / artemin / Q5T4W7* / Q9Z0L2*ENSGALG0000003209821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0001941 postsynaptic membrane organization IEA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021784 postganglionic parasympathetic fiber development IEA
 biological_processGO:0030432 peristalsis IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032770 positive regulation of monooxygenase activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048484 enteric nervous system development IEA
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0051584 regulation of dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0060676 ureteric bud formation IEA
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IEA
 biological_processGO:0060993 kidney morphogenesis NAS
 biological_processGO:0072107 positive regulation of ureteric bud formation IEA
 biological_processGO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex / reaction
 ENSGALG00000002583 PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*  / complex
 ENSGALG00000013100 GRB10 / growth factor receptor bound protein 10 / Q13322* / Q60760*  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000010688 SHC3 / SHC adaptor protein 3 / Q61120* / Q92529* / src homology 2 domain-containing transforming protein C3*  / reaction / complex
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction / complex
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex / reaction
 ENSGALG00000014701 RAP1GAP1 / RAP1 GTPase activating protein / P47736* / A2ALS5* / RAP1GAP* / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA.*  / complex / reaction
 ENSGALG00000025950 PRKCA / protein kinase C alpha / P17252*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex






 

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