ENSGALG00000010688


Gallus gallus

Features
Gene ID: ENSGALG00000010688
  
Biological name :SHC3
  
Synonyms : SHC3 / SHC adaptor protein 3
  
Possible biological names infered from orthology : Q61120 / Q92529 / src homology 2 domain-containing transforming protein C3
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 43451876
Gene end: 43520856
  
Corresponding Affymetrix probe sets: GgaAffx.6756.1.S1_at (Chicken Array)   GgaAffx.6756.1.S1_s_at (Chicken Array)   GgaAffx.6756.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017365
Ensembl peptide - ENSGALP00000056341
Ensembl peptide - ENSGALP00000051154
NCBI entrez gene - 431265     See in Manteia.
RefSeq - XM_004949245
RefSeq - XM_015280389
swissprot - E1C4D4
swissprot - A0A1D5PTU1
swissprot - A0A1D5PEF2
Ensembl - ENSGALG00000010688
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHC3ENSDARG00000098909Danio rerio
 SHC3ENSG00000148082Homo sapiens
 Shc3ENSMUSG00000021448Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHC2 / SHC adaptor protein 2 / P98077* / Q8BMC3* / SHC (Src homology 2 domain containing) transforming protein 2*ENSGALG0000000128947
SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *ENSGALG0000003977547
SHC4* / Q6S5L8* / Q6S5L9* / SHC adaptor protein 4* / SHC (Src homology 2 domain containing) family, member 4*ENSGALG000000050119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029593  SHC-transforming protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Signalling to RAS
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / reaction / complex
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / reaction / complex
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction






 

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