ENSMUSG00000021448


Mus musculus

Features
Gene ID: ENSMUSG00000021448
  
Biological name :Shc3
  
Synonyms : Q61120 / Shc3 / src homology 2 domain-containing transforming protein C3
  
Possible biological names infered from orthology : Q92529 / SHC adaptor protein 3
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A5
Gene start: 51431041
Gene end: 51569419
  
Corresponding Affymetrix probe sets: 10409222 (MoGene1.0st)   1450326_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021898
Ensembl peptide - ENSMUSP00000152080
NCBI entrez gene - 20418     See in Manteia.
MGI - MGI:106179
RefSeq - NM_009167
RefSeq Peptide - NP_033193
swissprot - Q3ZAX3
swissprot - Q61120
Ensembl - ENSMUSG00000021448
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHC3ENSDARG00000098909Danio rerio
 SHC3ENSGALG00000010688Gallus gallus
 SHC3ENSG00000148082Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*ENSMUSG0000004262654
Shc2 / Q8BMC3 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / SHC adaptor protein 2*ENSMUSG0000002031254
Shc4 / Q6S5L9 / SHC (Src homology 2 domain containing) family, member 4 / Q6S5L8* / SHC adaptor protein 4*ENSMUSG0000003510947


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029593  SHC-transforming protein 3
 IPR035676  SH2 adaptor protein C, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA


Pathways (from Reactome)
Pathway description
Signalling to RAS
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Sox3tm1Rlb/Y
Genetic Background: involves: 129S7/SvEvBrd * MF1

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
Show

Allelic Composition: Shc2tm1Paw/Shc2tm1Paw,Shc3tm1Paw/Shc3tm1Paw
Genetic Background: involves: 129/Sv

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Shc2tm1Paw/Shc2tm1Paw,Shc3tm1Paw/Shc3tm1Paw
Genetic Background: involves: 129/Sv

 MP:0000969 abnormal nociceptor morphology "anomalous structure of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Shc2tm1Paw/Shc2tm1Paw,Shc3tm1Paw/Shc3tm1Paw
Genetic Background: involves: 129/Sv

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Shc2tm1Paw/Shc2tm1Paw,Shc3tm1Paw/Shc3tm1Paw
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction






 

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