ENSG00000148082


Homo sapiens

Features
Gene ID: ENSG00000148082
  
Biological name :SHC3
  
Synonyms : Q92529 / SHC3 / SHC adaptor protein 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q22.1
Gene start: 89005771
Gene end: 89178767
  
Corresponding Affymetrix probe sets: 206330_s_at (Human Genome U133 Plus 2.0 Array)   229824_at (Human Genome U133 Plus 2.0 Array)   243881_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364991
Ensembl peptide - ENSP00000364995
NCBI entrez gene - 53358     See in Manteia.
OMIM - 605263
RefSeq - XM_011518786
RefSeq - NM_016848
RefSeq - XM_011518785
RefSeq Peptide - NP_058544
swissprot - Q92529
swissprot - Q5T7I8
Ensembl - ENSG00000148082
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SHC3ENSDARG00000098909Danio rerio
 SHC3ENSGALG00000010688Gallus gallus
 Shc3ENSMUSG00000021448Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHC1 / P29353 / SHC adaptor protein 1ENSG0000016069147
SHC2 / P98077 / SHC adaptor protein 2ENSG0000012994645
SHC4 / Q6S5L8 / SHC adaptor protein 4ENSG0000018563444


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029593  SHC-transforming protein 3
 IPR035676  SH2 adaptor protein C, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IBA


Pathways (from Reactome)
Pathway description
Signalling to RAS
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction






 

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