ENSGALG00000002583


Gallus gallus

Features
Gene ID: ENSGALG00000002583
  
Biological name :PIK3CD
  
Synonyms : phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / PIK3CD
  
Possible biological names infered from orthology : O00329 / O35904 / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  
Species: Gallus gallus
  
Chr. number: 21
Strand: 1
Band:
Gene start: 3417403
Gene end: 3489188
  
Corresponding Affymetrix probe sets: Gga.16295.1.S1_at (Chicken Array)   Gga.16782.1.S1_at (Chicken Array)   Gga.8789.1.S1_at (Chicken Array)   GgaAffx.25541.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004061
NCBI entrez gene - 419444     See in Manteia.
RefSeq - XM_015296890
RefSeq - NM_001012696
RefSeq - XM_015296888
RefSeq - XM_015296889
RefSeq Peptide - NP_001012714
swissprot - F1NHX1
Ensembl - ENSGALG00000002583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3cdENSDARG00000003250Danio rerio
 O00329ENSG00000171608Homo sapiens
 O35904ENSMUSG00000039936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *ENSGALG0000000550558
PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *ENSGALG0000000893440
PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma / P48736* / Q9JHG7* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform *ENSGALG0000000808130
PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSGALG0000003704327
PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSGALG0000000612127
PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma / O75747* / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 *ENSGALG0000001311722
PIK3C3 / phosphatidylinositol 3-kinase catalytic subunit type 3 / Q6PF93* / Q8NEB9*ENSGALG0000003577320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0033031 positive regulation of neutrophil apoptotic process IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005547 Q9DDT2 / PIK3AP1 / Phosphoinositide 3-kinase adapter protein 1 / Q6ZUJ8* / Q9EQ32* / phosphoinositide-3-kinase adaptor protein 1*  / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex
 ENSGALG00000010335 Q64143* / PIK3R3* / Q92569* / AL358075.4* / AL670603.1* / phosphoinositide-3-kinase regulatory subunit 3* / Phosphatidylinositol 3-kinase regulatory subunit gamma *  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / complex
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex
 ENSGALG00000031387 YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...  / complex / reaction






 

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