ENSGALG00000010335


Gallus gallus

Features
Gene ID: ENSGALG00000010335
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : AL358075.4 / AL670603.1 / Phosphatidylinositol 3-kinase regulatory subunit gamma / phosphoinositide-3-kinase regulatory subunit 3 / PIK3R3 / Q64143 / Q92569
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 21504570
Gene end: 21529508
  
Corresponding Affymetrix probe sets: GgaAffx.6526.1.S1_s_at (Chicken Array)   GgaAffx.6526.7.S1_at (Chicken Array)   GgaAffx.6526.7.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023820
NCBI entrez gene - 429096     See in Manteia.
RefSeq - XM_004936762
swissprot - E1C8M6
Ensembl - ENSGALG00000010335
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r3bENSDARG00000034409Danio rerio
 AL358075.4ENSG00000278139Homo sapiens
 PIK3R3ENSG00000117461Homo sapiens
 AL670603.1ENSMUSG00000111410Mus musculus
 Pik3r3ENSMUSG00000028698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*ENSGALG0000001478673
O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *ENSGALG0000000342867


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001720  PI3K p85/p55 subunit
 IPR032498  PI3K p85 subunit, inter-SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002583 PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*  / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex






 

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