ENSMUSG00000028698


Mus musculus

Features
Gene ID: ENSMUSG00000028698
  
Biological name :Pik3r3
  
Synonyms : Phosphatidylinositol 3-kinase regulatory subunit gamma / Pik3r3 / Q64143
  
Possible biological names infered from orthology : phosphoinositide-3-kinase regulatory subunit 3 / Q92569
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 116221618
Gene end: 116303056
  
Corresponding Affymetrix probe sets: 10507273 (MoGene1.0st)   1456482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118568
Ensembl peptide - ENSMUSP00000030464
Ensembl peptide - ENSMUSP00000102099
NCBI entrez gene - 18710     See in Manteia.
MGI - MGI:109277
RefSeq - XM_017320041
RefSeq - NM_181585
RefSeq - XM_006502859
RefSeq - XM_006502860
RefSeq - XM_006502861
RefSeq - XM_017320039
RefSeq - XM_017320040
RefSeq Peptide - NP_001342513
RefSeq Peptide - NP_001342514
RefSeq Peptide - NP_853616
swissprot - Q64143
swissprot - Q3UXE9
swissprot - B1AUG0
swissprot - B1AUF8
Ensembl - ENSMUSG00000028698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r3bENSDARG00000034409Danio rerio
 ENSGALG00000010335Gallus gallus
 PIK3R3ENSG00000117461Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL670603.1 / AL358075.4*ENSMUSG0000011141092
P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*ENSMUSG0000004141771
O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*ENSMUSG0000003183467


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001720  PI3K p85/p55 subunit
 IPR032498  PI3K p85 subunit, inter-SH2 domain
 IPR035020  PI3K p85 subunit, C-terminal SH2 domain
 IPR035022  PI3K p85 subunit, N-terminal SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IDA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex






 

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