Manteia

ENSMUSG00000031834

Mus musculus

Features

Gene ID:	ENSMUSG00000031834

Biological name :	Pik3r2

Synonyms :	O08908 / Phosphatidylinositol 3-kinase regulatory subunit beta / Pik3r2

Possible biological names infered from orthology :	AC007192.1 / O00459 / phosphoinositide-3-kinase regulatory subunit 2

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	B3.3
Gene start:	70768176
Gene end:	70776713

Corresponding Affymetrix probe sets:	10579356 (MoGene1.0st) 1418463_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000034296 Ensembl peptide - ENSMUSP00000121463 Ensembl peptide - ENSMUSP00000122065 NCBI entrez gene - 18709 See in Manteia. MGI - MGI:1098772 RefSeq - XM_006509600 RefSeq - NM_008841 RefSeq Peptide - NP_032867 swissprot - F6R2V5 swissprot - O08908 swissprot - F7CB91 Ensembl - ENSMUSG00000031834

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pik3r2	ENSDARG00000018060	Danio rerio
	ENSGALG00000003428	Gallus gallus
AC007192.1	ENSG00000268173	Homo sapiens
O00459	ENSG00000105647	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*	ENSMUSG00000041417	58
Pik3r3 / Q64143 / Phosphatidylinositol 3-kinase regulatory subunit gamma / Q92569* / phosphoinositide-3-kinase regulatory subunit 3*	ENSMUSG00000028698	43
AL670603.1 / AL358075.4*	ENSMUSG00000111410	43

Protein motifs (from Interpro)

Interpro ID	Name
IPR000198	Rho GTPase-activating protein domain
IPR000980	SH2 domain
IPR001452	SH3 domain
IPR001720	PI3K p85/p55 subunit
IPR008936	Rho GTPase activation protein
IPR032498	PI3K p85 subunit, inter-SH2 domain
IPR035020	PI3K p85 subunit, C-terminal SH2 domain
IPR035022	PI3K p85 subunit, N-terminal SH2 domain
IPR035586	Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001678	cellular glucose homeostasis	IDA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0008286	insulin receptor signaling pathway	IBA
biological_process	GO:0010506	regulation of autophagy	ISO
biological_process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0030833	regulation of actin filament polymerization	IMP
biological_process	GO:0032869	cellular response to insulin stimulus	IDA
biological_process	GO:0034976	response to endoplasmic reticulum stress	IDA
biological_process	GO:0042993	obsolete positive regulation of transcription factor import into nucleus	IMP
biological_process	GO:0043409	negative regulation of MAPK cascade	ISO
biological_process	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0051492	regulation of stress fiber assembly	IMP
biological_process	GO:1903076	regulation of protein localization to plasma membrane	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005925	focal adhesion	IDA
cellular_component	GO:0005942	phosphatidylinositol 3-kinase complex	IEA
molecular_function	GO:0001784	phosphotyrosine residue binding	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IPI
molecular_function	GO:0019903	protein phosphatase binding	ISO
molecular_function	GO:0030971	receptor tyrosine kinase binding	ISO
molecular_function	GO:0035014	phosphatidylinositol 3-kinase regulator activity	IEA
molecular_function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IPI
molecular_function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA
molecular_function	GO:0046982	protein heterodimerization activity	IPI

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Pik3cb^{tm1a(EUCOMM)Wtsi}/Pik3cb^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Pik3cb^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Shh^tm1Chg/Shh^tm1Chg Genetic Background: involves: C57BL/6
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Spi1^tm1Sing/Spi1⁺,Spib^tm1Mcs/Spib^tm1Mcs Genetic Background: involves: 129S/SvEv * 129X1/SvJ
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Shh^tm1Chg/Shh^tm1Chg Genetic Background: involves: C57BL/6
MP:0004565	small myocardial fiber	"decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Spi1^tm1Sing/Spi1⁺,Spib^tm1Mcs/Spib^tm1Mcs Genetic Background: involves: 129S/SvEv * 129X1/SvJ
MP:0005554	decreased circulating creatinine level	"less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Pik3cb^{tm1a(EUCOMM)Wtsi}/Pik3cb^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Pik3cb^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Shh^tm1Chg/Shh^tm1Chg Genetic Background: involves: C57BL/6
MP:0008014	lung tumor	"presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kras^tm4Tyj/Kras⁺,Pik3r1^tm1Lca/Pik3r1^tm1Lca,Pik3r2^tm1Lca/Pik3r2^tm1Lca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac Allelic Composition: Kras^tm4Tyj/Kras⁺,Pik3r1^tm1Lca/Pik3r1⁺,Pik3r2^tm1Lca/Pik3r2^tm1Lca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0010267	decreased lung tumor incidence	"less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abca12^tm1Lex/Abca12^tm1Lex Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000489	Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*	/ complex / reaction
ENSMUSG00000029231	P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*	/ complex / reaction
ENSMUSG00000002602	Axl / Q00993 / AXL receptor tyrosine kinase / P30530*	/ reaction / complex
ENSMUSG00000004508	Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*	/ complex / reaction
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ complex / reaction
ENSMUSG00000020170	Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*	/ complex
ENSMUSG00000024620	Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*	/ complex / reaction
ENSMUSG00000022309	Angpt1 / O08538 / Angiopoietin-1 / Q15389*	/ complex / reaction
ENSMUSG00000023992	Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*	/ reaction / complex
ENSMUSG00000023951	Vegfa / Q00731 / vascular endothelial growth factor A / P15692*	/ reaction / complex
ENSMUSG00000040751	Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*	/ reaction / complex
ENSMUSG00000028071	Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*	/ complex / reaction
ENSMUSG00000027665	P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*	/ complex
ENSMUSG00000031714	Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*	/ complex
ENSMUSG00000038894	Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*	/ reaction / complex
ENSMUSG00000027646	Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*	/ reaction / complex
ENSMUSG00000042626	Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*	/ reaction / complex
ENSMUSG00000030165	Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*	/ complex / reaction
ENSMUSG00000032462	Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*	/ complex
ENSMUSG00000030149	Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*	/ reaction / complex
ENSMUSG00000030579	O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*	/ complex / reaction
ENSMUSG00000039936	O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*	/ complex
ENSMUSG00000055980	Irs1 / insulin receptor substrate 1 / P35568*	/ complex / reaction
ENSMUSG00000062960	Kdr / kinase insert domain receptor / P35968*	/ complex / reaction
ENSMUSG00000028072	Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*	/ reaction / complex
ENSMUSG00000059089	Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*	/ complex / reaction
ENSMUSG00000021457	Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*	/ complex / reaction
ENSMUSG00000015947	Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*	/ complex / reaction
ENSMUSG00000025856	Pdgfa / platelet derived growth factor subunit A / P04085*	/ reaction / complex
ENSMUSG00000005763	Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*	/ complex / reaction
ENSMUSG00000002033	Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*	/ complex / reaction
ENSMUSG00000027859	Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*	/ reaction / complex
ENSMUSG00000024241	Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*	/ reaction / complex
ENSMUSG00000043733	P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ complex
ENSMUSG00000006386	Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*	/ complex / reaction
ENSMUSG00000000409	Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*	/ complex / reaction
ENSMUSG00000019843	Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*	/ reaction / complex
ENSMUSG00000060802	B2m / P01887 / Beta-2-microglobulin / P61769*	/ reaction / complex
ENSMUSG00000030775	Trat1 / T cell receptor associated transmembrane adaptor 1 / Q6PIZ9*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr