ENSMUSG00000023992


Mus musculus

Features
Gene ID: ENSMUSG00000023992
  
Biological name :Trem2
  
Synonyms : Q99NH8 / Trem2 / Triggering receptor expressed on myeloid cells 2
  
Possible biological names infered from orthology : Q9NZC2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 48346401
Gene end: 48354147
  
Corresponding Affymetrix probe sets: 10445781 (MoGene1.0st)   1421226_at (Mouse Genome 430 2.0 Array)   1421792_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024791
Ensembl peptide - ENSMUSP00000108863
NCBI entrez gene - 83433     See in Manteia.
MGI - MGI:1913150
RefSeq - NM_001272078
RefSeq - NM_031254
RefSeq Peptide - NP_001259007
RefSeq Peptide - NP_112544
swissprot - Q99NH8
Ensembl - ENSMUSG00000023992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TREM2ENSGALG00000023781Gallus gallus
 TREM2ENSG00000095970Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II IEA
 biological_processGO:0006911 phagocytosis, engulfment IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IC
 biological_processGO:0032497 detection of lipopolysaccharide IDA
 biological_processGO:0032499 detection of peptidoglycan IDA
 biological_processGO:0045087 innate immune response IC
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070392 detection of lipoteichoic acid IDA
 biological_processGO:0071223 cellular response to lipoteichoic acid IDA
 biological_processGO:0071224 cellular response to peptidoglycan IDA
 biological_processGO:0097028 dendritic cell differentiation IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway IEA
 biological_processGO:2000350 positive regulation of CD40 signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0042834 peptidoglycan binding IDA
 molecular_functionGO:0070891 lipoteichoic acid binding IDA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
DAP12 signaling
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001599 abnormal blood volume "anomalous amount of space occupied by the blood in the vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Trem2em1Bwef/Trem2+
Genetic Background: involves: C57BL/6J * DBA/2J * FVB/N

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010170 abnormal glial cell apoptosis "change in the timing or the number of glial cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0011986 decreased macrophage proliferation "reduced ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235]
Show

Allelic Composition: E2f4tm2.1Lees/E2f4tm2.1Lees,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0020449 decreased microglial cell activation "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
Show

Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay

Allelic Composition: Trem2em1Bwef/Trem2em1Bwef
Genetic Background: involves: C57BL/6J * DBA/2J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction
 ENSMUSG00000027200 Q76KF0 / Sema6d / Semaphorin-6D / Q8NFY4*  / reaction / complex
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex






 

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