Manteia - Molecule gene

ENSMUSG00000030579

Mus musculus

Features

Gene ID:	ENSMUSG00000030579

Biological name :	Tyrobp

Synonyms :	O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein

Possible biological names infered from orthology :	O43914

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	B1
Gene start:	30413760
Gene end:	30417585

Corresponding Affymetrix probe sets:	10551883 (MoGene1.0st) 1450792_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000032800 Ensembl peptide - ENSMUSP00000146653 Ensembl peptide - ENSMUSP00000146494 NCBI entrez gene - 22177 See in Manteia. MGI - MGI:1277211 RefSeq - NM_011662 RefSeq Peptide - NP_035792 swissprot - A0A140LHP7 swissprot - A0A140LI31 swissprot - O54885 swissprot - Q3U419 Ensembl - ENSMUSG00000030579

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tyrobp	ENSDARG00000094894	Danio rerio
O43914	ENSG00000011600	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR021157	Cytochrome c1, transmembrane anchor, C-terminal
IPR026200	TYRO protein tyrosine kinase-binding protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002281	macrophage activation involved in immune response	IMP
biological_process	GO:0002283	neutrophil activation involved in immune response	IMP
biological_process	GO:0007229	integrin-mediated signaling pathway	IMP
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:2001204	regulation of osteoclast development	IGI
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0042802	identical protein binding	IEA

Pathways (from Reactome)

Pathway description

DAP12 interactions

DAP12 signaling

Signal regulatory protein family interactions

Other semaphorin interactions

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0000065	abnormal bone marrow cavities	"absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000067	osteopetrosis	"excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10 Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000136	abnormal microglial cell morphology	"anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Hcst/Tyrobp^tm1Ttk/Hcst/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Aicda^tm1Hon/Aicda^tm4Mnz Genetic Background: involves: C57BL/6 * CBA
MP:0001728	failure of implantation	"inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002376	abnormal dendritic cell physiology	"failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Aicda^tm1Hon/Aicda^tm4Mnz Genetic Background: involves: C57BL/6 * CBA
MP:0002635	reduced sensorimotor gating		Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0002910	abnormal excitatory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0002945	abnormal inhibitory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10
MP:0003008	enhanced long term potentiation	"greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0003080	competent NK cell cytolysis	"ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003436	resistance to induced arthritis	"less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]	Show Allelic Composition: Tubb3^tm1.1Ece/Tubb3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003795	abnormal bone structure		Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004256	abnormal maternal decidual layer morphology	"anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004259	small placenta	"reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004260	enlarged placenta	"increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004982	abnormal osteoclast morphology	"any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004993	decreased bone resorption	"reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005025	response to infection	"the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: B6.129P2-Tyrobp^tm1Lll
MP:0005070	defective NK cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]	Show Allelic Composition: Zbtb7b^tm2Litt/Zbtb7b^tm2Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0005605	increased bone mass	"an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005616	decreased susceptibility to type IV hypersensitivity reaction	"less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zbtb7b^tm2Litt/Zbtb7b^tm2Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0008042	abnormal NK T cell physiology	"any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Chrnb2^tm1Jpc/Chrnb2^tm1Jpc Genetic Background: B6.129P2-Chrnb2^tm1Jpc Allelic Composition: Hcst^tm1.1Cln/Hcst^tm1.1Cln,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: B6.Cg-Hcst^tm1.1Cln Tyrobp^tm1Lll
MP:0008126	increased dendritic cell number	"greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zbtb7b^tm2Litt/Zbtb7b^tm2Litt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008158	increased diameter of femur	"increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008177	increased germinal center B cell number	"greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008481	increased spleen germinal center number	"greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008483	increased spleen germinal center size	"greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008500	increased IgG2a level	"greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008502	increased IgG3 level	"greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: B6.129P2-Tyrobp^tm1Lll
MP:0008705	increased interleukin-6 secretion	"increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0008876	decreased uterine NK cell number	"reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10 Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010872	increased trabecular bone mass	"greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tal1^tm3Wehi/Tal1^tm2Wehi,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0010878	increased trabecular bone volume	"increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: B6.129P2-Tyrobp^tm1.1Viv Allelic Composition: Oscar^tm1Ywc/Oscar^tm1Ywc,Tyrobp^tm1Ttk/Tyrobp^tm1Ttk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010932	increased trabecular bone connectivity density	"increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10
MP:0012529	abnormal decidua basalis morphology	"any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012726	abnormal uterine spiral artery morphology	"any structural anomaly of the corkscrew-like arteries in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change)" [MGI:anna]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012727	abnormal uterine spiral artery remodeling	"any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor" [MGI:anna]	Show Allelic Composition: Il4^tm1.1Wep/Il4^tm1.1Wep Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0030072	round face	"facial appearance is more circular than usual as viewed from the front" [HP:0000311]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Tyrobp^tm1Lll/Tyrobp^tm1Lll Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000030149	Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*	/ complex / reaction
ENSMUSG00000031834	O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*	/ complex / reaction
ENSMUSG00000021457	Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*	/ complex / reaction
ENSMUSG00000027665	P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*	/ reaction / complex
ENSMUSG00000060802	B2m / P01887 / Beta-2-microglobulin / P61769*	/ reaction / complex
ENSMUSG00000091055	Siglec15 / sialic acid binding Ig-like lectin 15 / Q6ZMC9*	/ reaction / complex
ENSMUSG00000032462	Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*	/ reaction / complex
ENSMUSG00000023992	Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*	/ complex / reaction
ENSMUSG00000042265	Trem1 / Q9JKE2 / triggering receptor expressed on myeloid cells 1 / Q9NP99*	/ reaction / complex
ENSMUSG00000030579	O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*	/ complex / reaction
ENSMUSG00000079852	Klra4 / Q60651 / Mus musculus killer cell lectin-like receptor, subfamily A, member 18 (Klra18), mRNA.	/ complex
ENSMUSG00000063193	Cd300lb / Mus musculus CD300 molecule like family member B (Cd300lb), transcript variant 2, mRNA. / A8K4G0* / CD300 molecule like family member b*	/ complex / reaction
ENSMUSG00000041417	P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*	/ complex / reaction
ENSMUSG00000029915	Clec5a / Q9R007 / C-type lectin domain family 5 member A / Q9NY25* / C-type lectin domain containing 5A*	/ complex / reaction
ENSMUSG00000000409	Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*	/ complex / reaction
ENSMUSG00000048498	Cd300e / Q8K249 / CMRF35-like molecule 2 / Q496F6* / CD300e molecule*	/ complex / reaction
ENSMUSG00000019843	Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*	/ complex / reaction
ENSMUSG00000030165	Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*	/ complex / reaction
ENSMUSG00000027200	Q76KF0 / Sema6d / Semaphorin-6D / Q8NFY4*	/ complex / reaction
ENSMUSG00000030084	P70206 / Plxna1 / Plexin-A1 / Q9UIW2*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr