ENSMUSG00000030149


Mus musculus

Features
Gene ID: ENSMUSG00000030149
  
Biological name :Klrk1
  
Synonyms : Klrk1 / NKG2-D type II integral membrane protein / O54709
  
Possible biological names infered from orthology : killer cell lectin like receptor K1 / P26718
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 129610323
Gene end: 129623864
  
Corresponding Affymetrix probe sets: 10548345 (MoGene1.0st)   1450495_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032252
Ensembl peptide - ENSMUSP00000093061
Ensembl peptide - ENSMUSP00000130398
NCBI entrez gene - 27007     See in Manteia.
MGI - MGI:1196250
RefSeq - XM_011241369
RefSeq - NM_001083322
RefSeq - NM_001286018
RefSeq - NM_033078
RefSeq Peptide - NP_001272947
RefSeq Peptide - NP_149069
RefSeq Peptide - NP_001076791
swissprot - O54709
swissprot - Q3TCW7
swissprot - Q4FJM0
Ensembl - ENSMUSG00000030149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLRK1ENSG00000213809Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klre1 / Q8CJC7 / Killer cell lectin-like receptor subfamily E member 1 ENSMUSG0000005024126
Klrc2 / KLRC1* / KLRC4* / KLRC3* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000005273622
Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*ENSMUSG0000003016522
Klrc1 / KLRC4* / KLRC3* / KLRC2* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000003016720
Klri2 / Q5DT36 / Killer cell lectin-like receptor subfamily I member 2 ENSMUSG0000004393220
Klrc3 / KLRC1* / KLRC4* / KLRC2* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000003302720
Klri1 / B2KG20 / Killer cell lectin-like receptor subfamily I member 1 ENSMUSG0000006761020


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0030101 natural killer cell activation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:2000502 negative regulation of natural killer cell chemotaxis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0032394 MHC class Ib receptor activity IMP
 molecular_functionGO:0042288 MHC class I protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

Allelic Composition: Klrk1tm2.1Bpol/Klrk1tm2.1Bpol
Genetic Background: Not Specified

 MP:0003080 competent NK cell cytolysis "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]
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Allelic Composition: GnaqM1J/Gnaq+
Genetic Background: C57BL/6J-GnaqM1J/GrsrJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpr183tm1.2Rbr/Gpr183tm1.2Rbr,Ightm1Rbr/Ightm1Rbr,Tg(IgkHyHEL10)1Rbr/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

Allelic Composition: Klrk1tm2.1Bpol/Klrk1tm2.1Bpol
Genetic Background: Not Specified

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Klrk1tm1.1Bpol/Klrk1tm1.1Bpol
Genetic Background: C57BL/6-Klrk1tm1.1Bpol

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000030149 Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000054005 Mill1 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*  / complex / reaction
 ENSMUSG00000040987 Mill2 / MHC I like leukocyte 2 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*  / reaction / complex
 ENSMUSG00000064109 Hcst / Q9QUJ0 / Hematopoietic cell signal transducer / Q9UBK5*  / complex
 ENSMUSG00000079685 Ulbp1 / UL16 binding protein 1 / ULBP3* / ULBP2* / Q9BZM5* / RAET1G* / RAET1L* / Q9BZM4* / Q6H3X3* / Q5VY80* / Q9BZM6* / UL16 binding protein 3* / UL16 binding protein 2* / retinoic acid ea...  / reaction / complex






 

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