ENSMUSG00000030167


Mus musculus

Features
Gene ID: ENSMUSG00000030167
  
Biological name :Klrc1
  
Synonyms : Klrc1
  
Possible biological names infered from orthology : AC068775.1 / killer cell lectin like receptor C1 / killer cell lectin like receptor C2 / killer cell lectin like receptor C3 / killer cell lectin like receptor C4 / KLRC2 / KLRC3 / KLRC4 / KLRC4-KLRK1 / KLRC4-KLRK1 readthrough / O43908 / P26715 / P26717 / Q07444
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 129666015
Gene end: 129678973
  
Corresponding Affymetrix probe sets: 10548409 (MoGene1.0st)   1425005_at (Mouse Genome 430 2.0 Array)   1426182_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032270
Ensembl peptide - ENSMUSP00000032271
Ensembl peptide - ENSMUSP00000114017
Ensembl peptide - ENSMUSP00000130762
NCBI entrez gene - 16641     See in Manteia.
MGI - MGI:1336161
RefSeq - XM_017321418
RefSeq - NM_001136068
RefSeq - NM_001288664
RefSeq - NM_010652
RefSeq - XM_011241236
RefSeq - XM_011241237
RefSeq Peptide - NP_034782
RefSeq Peptide - NP_001129540
RefSeq Peptide - NP_001275593
swissprot - Q9WU32
swissprot - Q9Z202
swissprot - E9QAJ6
Ensembl - ENSMUSG00000030167
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC068775.1ENSG00000255641Homo sapiens
 KLRC1ENSG00000134545Homo sapiens
 KLRC2ENSG00000205809Homo sapiens
 KLRC3ENSG00000205810Homo sapiens
 KLRC4ENSG00000183542Homo sapiens
 KLRC4-KLRK1ENSG00000255819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klrc2 / KLRC1* / KLRC4* / KLRC3* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000005273665
Klrc3 / KLRC1* / KLRC4* / KLRC2* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000003302763
Klre1 / Q8CJC7 / Killer cell lectin-like receptor subfamily E member 1 ENSMUSG0000005024121
Klri1 / B2KG20 / Killer cell lectin-like receptor subfamily I member 1 ENSMUSG0000006761020
Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*ENSMUSG0000003014919
Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*ENSMUSG0000003016517
Klri2 / Q5DT36 / Killer cell lectin-like receptor subfamily I member 2 ENSMUSG0000004393216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0023024 MHC class I protein complex binding ISO
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
DAP12 interactions
DAP12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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