ENSMUSG00000050241


Mus musculus

Features
Gene ID: ENSMUSG00000050241
  
Biological name :Klre1
  
Synonyms : Killer cell lectin-like receptor subfamily E member 1 / Klre1 / Q8CJC7
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F3
Gene start: 129577905
Gene end: 129585827
  
Corresponding Affymetrix probe sets: 10542205 (MoGene1.0st)   1458642_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055779
Ensembl peptide - ENSMUSP00000145085
NCBI entrez gene - 243655     See in Manteia.
MGI - MGI:2662547
RefSeq - XM_017321589
RefSeq - NM_153590
RefSeq - XM_006506123
RefSeq - XM_006506126
RefSeq - XM_006506128
RefSeq - XM_006506121
RefSeq Peptide - NP_705818
swissprot - Q8CJC7
swissprot - A0A0N4SVG0
Ensembl - ENSMUSG00000050241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*ENSMUSG0000003014927
Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*ENSMUSG0000003016527
Klrc1 / KLRC4* / KLRC3* / KLRC2* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000003016723
Klri1 / B2KG20 / Killer cell lectin-like receptor subfamily I member 1 ENSMUSG0000006761022
Klri2 / Q5DT36 / Killer cell lectin-like receptor subfamily I member 2 ENSMUSG0000004393219
Klrc2 / KLRC1* / KLRC4* / KLRC3* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000005273619
Klrc3 / KLRC1* / KLRC4* / KLRC2* / Q07444* / O43908* / P26715* / P26717* / AC068775.1* / KLRC4-KLRK1* / KLRC4-KLRK1 readthrough* / killer cell lectin like receptor C1* / killer cell lectin ...ENSMUSG0000003302717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway IDA
 biological_processGO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0030101 natural killer cell activation IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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