ENSMUSG00000064109


Mus musculus

Features
Gene ID: ENSMUSG00000064109
  
Biological name :Hcst
  
Synonyms : Hcst / Hematopoietic cell signal transducer / Q9QUJ0
  
Possible biological names infered from orthology : Q9UBK5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30417712
Gene end: 30419854
  
Corresponding Affymetrix probe sets: 10561920 (MoGene1.0st)   1419119_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074573
Ensembl peptide - ENSMUSP00000146793
NCBI entrez gene - 23900     See in Manteia.
MGI - MGI:1344360
RefSeq - NM_011827
RefSeq Peptide - NP_035957
swissprot - Q9QUJ0
Ensembl - ENSMUSG00000064109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HCSTENSG00000126264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009861  Hematopoietic cell signal transducer


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0050776 regulation of immune response IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IBA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Hcst/Tyrobptm1Ttk/Hcst/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hlftm1Schb/Hlftm1Schb,Teftm1Schb/Teftm1Schb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hcsttm1.1Cln/Hcsttm1.1Cln,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: B6.Cg-Hcsttm1.1Cln Tyrobptm1Lll

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

Allelic Composition: Hcsttm1.1Cln/Hcsttm1.1Cln,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: B6.Cg-Hcsttm1.1Cln Tyrobptm1Lll

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pigrtm1Ohw/Pigrtm1Ohw,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: involves: 129P2/OlaHsd

 MP:0012529 abnormal decidua basalis morphology "any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta" [MGI:anna]
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Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054005 Mill1 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*  / reaction / complex
 ENSMUSG00000040987 Mill2 / MHC I like leukocyte 2 / MICA* / MICB* / Q29980* / MHC class I polypeptide-related sequence A* / MHC class I polypeptide-related sequence B*  / reaction / complex
 ENSMUSG00000030149 Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*  / complex
 ENSMUSG00000064109 Hcst / Q9QUJ0 / Hematopoietic cell signal transducer / Q9UBK5*  / complex
 ENSMUSG00000079685 Ulbp1 / UL16 binding protein 1 / ULBP3* / ULBP2* / Q9BZM5* / RAET1G* / RAET1L* / Q9BZM4* / Q6H3X3* / Q5VY80* / Q9BZM6* / UL16 binding protein 3* / UL16 binding protein 2* / retinoic acid ea...  / complex / reaction






 

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