ENSG00000213809


Homo sapiens

Features
Gene ID: ENSG00000213809
  
Biological name :KLRK1
  
Synonyms : killer cell lectin like receptor K1 / KLRK1 / P26718
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.2
Gene start: 10372353
Gene end: 10391874
  
Corresponding Affymetrix probe sets: 1555691_a_at (Human Genome U133 Plus 2.0 Array)   205821_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379726
Ensembl peptide - ENSP00000240618
Ensembl peptide - ENSP00000446003
NCBI entrez gene - 100528032     See in Manteia.
NCBI entrez gene - 22914     See in Manteia.
OMIM - 611817
RefSeq - NM_001199805
RefSeq - NM_007360
RefSeq Peptide - NP_031386
RefSeq Peptide - NP_001186734
swissprot - Q8WZ67
swissprot - P26718
swissprot - A0A024RAP8
Ensembl - ENSG00000213809
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Klrk1ENSMUSG00000030149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLRD1 / Q13241 / killer cell lectin like receptor D1ENSG0000013453923
AC068775.1ENSG0000025564119
KLRC1 / P26715 / killer cell lectin like receptor C1ENSG0000013454519
KLRC3 / Q07444 / killer cell lectin like receptor C3ENSG0000020581019
KLRC2 / P26717 / killer cell lectin like receptor C2ENSG0000020580918
KLRC4-KLRK1 / KLRC4-KLRK1 readthroughENSG0000025581910
KLRC4 / O43908 / killer cell lectin like receptor C4ENSG0000018354210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030101 natural killer cell activation TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:2000502 negative regulation of natural killer cell chemotaxis IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0032394 MHC class Ib receptor activity IEA
 molecular_functionGO:0042288 MHC class I protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
DAP12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000011600 O43914 / TYROBP / TYRO protein tyrosine kinase binding protein  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000213809 KLRK1 / P26718 / killer cell lectin like receptor K1  / complex
 ENSG00000126264 HCST / Q9UBK5 / hematopoietic cell signal transducer  / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex






 

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