ENSG00000134539


Homo sapiens

Features
Gene ID: ENSG00000134539
  
Biological name :KLRD1
  
Synonyms : killer cell lectin like receptor D1 / KLRD1 / Q13241
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.2
Gene start: 10226058
Gene end: 10329600
  
Corresponding Affymetrix probe sets: 207795_s_at (Human Genome U133 Plus 2.0 Array)   207796_x_at (Human Genome U133 Plus 2.0 Array)   210606_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441074
Ensembl peptide - ENSP00000438669
Ensembl peptide - ENSP00000443584
Ensembl peptide - ENSP00000310929
Ensembl peptide - ENSP00000338130
Ensembl peptide - ENSP00000344858
Ensembl peptide - ENSP00000371333
Ensembl peptide - ENSP00000437880
Ensembl peptide - ENSP00000438514
NCBI entrez gene - 3824     See in Manteia.
OMIM - 602894
RefSeq - XM_017019291
RefSeq - NM_007334
RefSeq - XM_006719067
RefSeq - XM_011520650
RefSeq - XM_011520651
RefSeq - XM_017019285
RefSeq - XM_017019286
RefSeq - XM_017019287
RefSeq - XM_017019288
RefSeq - XM_017019289
RefSeq - XM_017019290
RefSeq - NM_001114396
RefSeq - NM_002262
RefSeq Peptide - NP_031360
RefSeq Peptide - NP_001107868
RefSeq Peptide - NP_001337991
RefSeq Peptide - NP_002253
swissprot - F5GX94
swissprot - E9PCX9
swissprot - Q13241
swissprot - F5H2B7
swissprot - F6WZH4
swissprot - H0YFB8
Ensembl - ENSG00000134539
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Klrd1ENSMUSG00000030165Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLRC2 / P26717 / killer cell lectin like receptor C2ENSG0000020580930
KLRC1 / P26715 / killer cell lectin like receptor C1ENSG0000013454529
KLRC3 / Q07444 / killer cell lectin like receptor C3ENSG0000020581029
AC068775.1ENSG0000025564129
KLRK1 / P26718 / killer cell lectin like receptor K1ENSG0000021380927
KLRC4 / O43908 / killer cell lectin like receptor C4ENSG0000018354215
KLRC4-KLRK1 / KLRC4-KLRK1 readthroughENSG0000025581915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002228 natural killer cell mediated immunity IDA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0050776 regulation of immune response TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0023024 MHC class I protein complex binding IPI
 molecular_functionGO:0023030 MHC class Ib protein binding, via antigen binding groove IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:1990405 protein antigen binding IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
DAP12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000011600 O43914 / TYROBP / TYRO protein tyrosine kinase binding protein  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / reaction / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000134545 KLRC1 / P26715 / killer cell lectin like receptor C1  / reaction / complex
 ENSG00000205809 KLRC2 / P26717 / killer cell lectin like receptor C2  / complex






 

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