ENSMUSG00000024620


Mus musculus

Features
Gene ID: ENSMUSG00000024620
  
Biological name :Pdgfrb
  
Synonyms : Pdgfrb / platelet-derived growth factor receptor beta isoform 2
  
Possible biological names infered from orthology : P09619 / platelet derived growth factor receptor beta
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 61045150
Gene end: 61085061
  
Corresponding Affymetrix probe sets: 10456046 (MoGene1.0st)   1417148_at (Mouse Genome 430 2.0 Array)   1436970_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025522
Ensembl peptide - ENSMUSP00000110929
NCBI entrez gene - 18596     See in Manteia.
MGI - MGI:97531
RefSeq - NM_001146268
RefSeq - NM_008809
RefSeq Peptide - NP_001139740
RefSeq Peptide - NP_032835
swissprot - E9QPE2
swissprot - E9QN12
Ensembl - ENSMUSG00000024620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfrbENSDARG00000100897Danio rerio
 PDGFRBENSGALG00000030613Gallus gallus
 P09619ENSG00000113721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923143
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567230
Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*ENSMUSG0000002462130
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964827
Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*ENSMUSG0000002035726
Kdr / kinase insert domain receptor / P35968*ENSMUSG0000006296026
Flt3 / fms related tyrosine kinase 3 / P36888*ENSMUSG0000004281724
Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*ENSMUSG0000003156521
Fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSMUSG0000000532020
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084920
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425220
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027288  Platelet-derived growth factor receptor beta
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006024 glycosaminoglycan biosynthetic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010863 positive regulation of phospholipase C activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035789 metanephric mesenchymal cell migration IEA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060437 lung growth IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072075 metanephric mesenchyme development IEA
 biological_processGO:0072275 metanephric glomerulus morphogenesis IEA
 biological_processGO:0072278 metanephric comma-shaped body morphogenesis IEA
 biological_processGO:0072284 metanephric S-shaped body morphogenesis IEA
 biological_processGO:2000491 positive regulation of hepatic stellate cell activation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043202 lysosomal lumen IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005017 platelet-derived growth factor-activated receptor activity IEA
 molecular_functionGO:0005019 platelet-derived growth factor beta-receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0038085 vascular endothelial growth factor binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0048407 platelet-derived growth factor binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Prm-cre)70Og/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Prm-cre)70Og/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm9Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Schip1Gt(ROSA)77Sor/Schip1Gt(ROSA)77Sor
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm9Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Prm-cre)70Og/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pdgfratm1Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pdgfratm1Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Sgpl1Gt(ROSA)78Sor/Sgpl1Gt(ROSA)78Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Schip1Gt(ROSA)77Sor/Schip1Gt(ROSA)77Sor
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Cdc42tm1Yizh/Cdc42tm1Yizh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0002635 reduced sensorimotor gating 
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm9Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm9Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm4Sor/Pdgfrbtm4Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm3Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm4Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm9Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004125 abnormal venule morphology "any structural anomaly in the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Brd/Rb1+,Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm2Msas/Pdgfrbtm2Msas,Tg(Nes-cre)1Nogu/?
Genetic Background: involves: 129 * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Schip1Gt(ROSA)77Sor/Schip1Gt(ROSA)77Sor
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0005327 abnormal mesangial cell "anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57971]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm4Sor/Pdgfrbtm4Sor
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Schip1Gt(ROSA)77Sor/Schip1Gt(ROSA)77Sor
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Schip1Gt(ROSA)77Sor/Schip1Gt(ROSA)77Sor
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006185 retinal hemorrhage "bleeding into the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0006203 eye hemorrhage "bleeding into the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0006253 clinodactyly "abnormal lateral curvature of one or more digits towards or away from each other" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:98519]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0008137 absent podocytes "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm1Brd/Rb1+,Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0008856 fetal bleb "presence of subepidermal blister-like structures on the skin, often on the head, formed during embryonic development and usually filled with blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0008903 abnormal mesenteric fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mesentery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfratm5Sor/Pdgfratm5Sor,Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm8Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm9Sor
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0009867 abnormal ascending aorta morphology "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009869 abnormal descending aorta morphology "any strucutral anomaly of the part of the aorta extending from the arch of aorta to the point where it divides into the common iliac arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0009870 abnormal abdominal aorta morphology "any structural anomaly of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, and supplies oxygenated blood to all of the abdominal and pelvic organs and the legs" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0010468 abnormal thoracic aorta morphology "any structural anomaly of the part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010488 abnormal left subclavian artery morphology "any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbb2b2903Clo/Pdgfrbb2b2903Clo
Genetic Background: C57BL/6J-Pdgfrbb2b2903Clo

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Tg(Prm-cre)70Og/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0011156 abnormal hypodermis fat layer morphology "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011359 decreased glomerular capillary number "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [MGI:csmith]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0011429 absent mesangial cell "absence of the phagocytic cells in the capillary tuft of the renal glomerulus, normally interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0011437 glomerulus hemorrhage "bleeding in the renal glomerulus" [MGI:anna]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Pdgfrbtm4Sor/Pdgfrbtm4Sor
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
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Allelic Composition: Ckbtm1Bew/Ckbtm1Bew,Ckmt1tm2Bew/Ckmt1tm2Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Rsd/Six1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011515 purpura "a smooth, moderately sized hemorrhagic area, typically dark red to reddish purple, resulting from extarvasation of blood into the skin, mucous membrane, or serosal surface; a pupura becomes brown-yellow as it fades and does not blanch on applying pressure" [MGI:anna]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm1Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Pdgfrbtm2Sor/Pdgfrbtm2Sor
Genetic Background: either: 129S7/SvEvBrd-Pdgfrbtm2Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Pdgfrbtm4Sor/Pdgfrbtm4Sor
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0011706 abnormal fibroblast migration "any anomaly of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [GO:0010761]
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Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J

 MP:0012752 abnormal cardiac neural crest cell migration "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm1Mdt/Pdgfrbtm1Mdt,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Nox3het-4J/Nox3het-4J
Genetic Background: C57BL/6J-Nox3het-4J/J

 MP:0014179 abnormal blood-retinal barrier function "anomaly in the function of the part of the blood-ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina; the BRB consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina; the BRB barrier becomes more leaky in patients with diabetic retinopathy" [https://en.wikipedia.org/wiki/Blood%E2%80%93retinal_barrier]
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Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Pdgfrbredeye/Pdgfrbredeye
Genetic Background: C3N.C-Pdgfrbredeye

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / reaction / complex






 

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