ENSMUSG00000005320


Mus musculus

Features
Gene ID: ENSMUSG00000005320
  
Biological name :Fgfr4
  
Synonyms : Fgfr4 / fibroblast growth factor receptor 4
  
Possible biological names infered from orthology : P22455
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55152640
Gene end: 55168759
  
Corresponding Affymetrix probe sets: 10405380 (MoGene1.0st)   1418596_at (Mouse Genome 430 2.0 Array)   1427776_a_at (Mouse Genome 430 2.0 Array)   1427777_x_at (Mouse Genome 430 2.0 Array)   1427845_at (Mouse Genome 430 2.0 Array)   1427846_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005452
NCBI entrez gene - 14186     See in Manteia.
MGI - MGI:95525
RefSeq - XM_006517100
RefSeq - NM_008011
RefSeq - XM_006517099
RefSeq Peptide - NP_032037
swissprot - A0A0R4IZY3
Ensembl - ENSMUSG00000005320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgfr4ENSDARG00000069105Danio rerio
 FGFR4ENSGALG00000028543Gallus gallus
 FGFR4ENSG00000160867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425259
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084957
Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*ENSMUSG0000003156556
Kdr / kinase insert domain receptor / P35968*ENSMUSG0000006296031
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011030
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964830
Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*ENSMUSG0000002035729
Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*ENSMUSG0000002462028
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567228
Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*ENSMUSG0000002462127
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923126
Flt3 / fms related tyrosine kinase 3 / P36888*ENSMUSG0000004281725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016248  Fibroblast growth factor receptor family
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010715 regulation of extracellular matrix disassembly IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070857 regulation of bile acid biosynthetic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005007 fibroblast growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
FGFR4 ligand binding and activation
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001184 absent alveoli "missing section of the lung in which gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fut2tm1Sdo/Fut2tm1Sdo
Genetic Background: B6.129X1-Fut2tm1Sdo

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fut2tm1Sdo/Fut2tm1Sdo
Genetic Background: B6.129X1-Fut2tm1Sdo

 MP:0001272 increased metastatic potential 
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

Allelic Composition: Fgfr4tm1Axul/Fgfr4tm1Axul,Tg(WapTgfa)215Bri/0
Genetic Background: B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

Allelic Composition: Fgfr4tm1Axul/Fgfr4tm1Axul,Tg(WapTgfa)215Bri/0
Genetic Background: B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri

Allelic Composition: Fgfr4tm1Axul/Fgfr4tm1Axul,Tg(WapTgfa)215Bri/0
Genetic Background: FVB.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr4tm1Axul/Fgfr4tm1Axul,Tg(WapTgfa)215Bri/0
Genetic Background: FVB.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Fgfr3tm1Led/Fgfr3tm1Led,Fgfr4tm1Cxd/Fgfr4tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0010266 decreased liver tumor incidence "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / reaction / complex
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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