ENSMUSG00000029195


Mus musculus

Features
Gene ID: ENSMUSG00000029195
  
Biological name :Klb
  
Synonyms : Beta-klotho / Klb / Q99N32
  
Possible biological names infered from orthology : klotho beta / Q86Z14
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 65348314
Gene end: 65384007
  
Corresponding Affymetrix probe sets: 10522127 (MoGene1.0st)   1426075_at (Mouse Genome 430 2.0 Array)   1449568_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031096
Ensembl peptide - ENSMUSP00000145091
NCBI entrez gene - 83379     See in Manteia.
MGI - MGI:1932466
RefSeq - XM_006504204
RefSeq - NM_031180
RefSeq Peptide - NP_112457
swissprot - Q99N32
swissprot - S4W6E2
Ensembl - ENSMUSG00000029195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klbENSDARG00000076294Danio rerio
 KLBENSGALG00000041663Gallus gallus
 KLBENSG00000134962Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*ENSMUSG0000005848844
Lct / lactase / P09848*ENSMUSG0000002635435
Lctl / Q8K1F9 / Lactase-like protein / Q6UWM7* / lactase like*ENSMUSG0000003240118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001360  Glycoside hydrolase family 1
 IPR017853  Glycoside hydrolase superfamily
 IPR033132  Glycosyl hydrolases family 1, N-terminal conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:1901657 glycosyl compound metabolic process IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017134 fibroblast growth factor binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0003457 abnormal circulating ketone body level "aberrant amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0003959 abnormal lean body mass "aberrant fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0004891 abnormal adiponectin level "abnormal level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0005457 abnormal percent body fat "more or less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0005667 abnormal circulating leptin level "aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0005675 small gall bladder "reduced size of the gall bladder, the organ that serves as a storage reservoir for bile" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:25724]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klbtm1.2Sakl/Klb+,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

 MP:0012320 abnormal body fat mass "aberrant fat-containing physical bulk or volume of the body" [MPD:Molly]
Show

Allelic Composition: Klbtm1.1Akha/Klbtm1.1Akha
Genetic Background: C57BL/6-Klbtm1.1Akha

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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