ENSGALG00000041663


Gallus gallus

Features
Gene ID: ENSGALG00000041663
  
Biological name :KLB
  
Synonyms : KLB / klotho beta
  
Possible biological names infered from orthology : Beta-klotho / Q86Z14 / Q99N32
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 69722650
Gene end: 69738298
  
Corresponding Affymetrix probe sets: GgaAffx.9076.1.S1_at (Chicken Array)   GgaAffx.94.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055913
NCBI entrez gene - 425467     See in Manteia.
RefSeq - XM_003641245
swissprot - A0A1D5PSM6
Ensembl - ENSGALG00000041663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klbENSDARG00000076294Danio rerio
 KLBENSG00000134962Homo sapiens
 KlbENSMUSG00000029195Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*ENSGALG0000001706844
LCT / lactase-phlorizin hydrolase precursor / P09848* / lactase*ENSGALG0000001226037
LCTL / lactase like / Q6UWM7* / Q8K1F9* / Lactase-like protein *ENSGALG0000004500613
GBA3* / glucosylceramidase beta 3 (gene/pseudogene)*ENSGALG000000402084


Protein motifs (from Interpro)
Interpro ID Name
 IPR001360  Glycoside hydrolase family 1
 IPR017853  Glycoside hydrolase superfamily
 IPR033132  Glycosyl hydrolases family 1, N-terminal conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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