ENSMUSG00000042817


Mus musculus

Features
Gene ID: ENSMUSG00000042817
  
Biological name :Flt3
  
Synonyms : Flt3 / fms related tyrosine kinase 3
  
Possible biological names infered from orthology : P36888
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G3
Gene start: 147330741
Gene end: 147400489
  
Corresponding Affymetrix probe sets: 10535780 (MoGene1.0st)   1419538_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039041
NCBI entrez gene - 14255     See in Manteia.
MGI - MGI:95559
RefSeq - NM_010229
RefSeq Peptide - NP_034359
swissprot - Q3UEW6
Ensembl - ENSMUSG00000042817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flt3ENSDARG00000058503Danio rerio
 FLT3ENSGALG00000035726Gallus gallus
 FLT3ENSG00000122025Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*ENSMUSG0000002462129
Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*ENSMUSG0000000567229
P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*ENSMUSG0000002923128
Flt4 / P35917 / Vascular endothelial growth factor receptor 3 / P35916* / fms related tyrosine kinase 4*ENSMUSG0000002035726
Flt1 / fms related tyrosine kinase 1 / P17948*ENSMUSG0000002964826
Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*ENSMUSG0000002462026
Kdr / kinase insert domain receptor / P35968*ENSMUSG0000006296026
Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*ENSMUSG0000003011021
Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*ENSMUSG0000003156521
Fgfr2 / fibroblast growth factor receptor 2 isoform 3 / P21802* / fibroblast growth factor receptor 2*ENSMUSG0000003084921
Fgfr3 / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA. / P22607* / fibroblast growth factor receptor 3*ENSMUSG0000005425221
Fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSMUSG0000000532020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR030118  Receptor-type tyrosine-protein kinase FLT3
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0043621 protein self-association IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Other interleukin signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tead2tm1.1Mldp/Tead2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tead2tm1.1Mldp/Tead2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: NOD.MRL-Faslpr

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

Allelic Composition: Flt3tm1Irl/Flt3tm1Irl,KitW/KitW-v
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

Allelic Composition: Flt3tm1Irl/Flt3tm1Irl,KitW/KitW-v
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Flt3tm1Irl/Flt3tm1Irl,KitW/KitW-v
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm1Dgg/Flt3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008618 decreased circulating interleukin-12 level "reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

Allelic Composition: Flt3tm1.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm1.1Dosm

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Flt3m1Btlr/Flt3m1Btlr
Genetic Background: C57BL/6J-Flt3m1Btlr

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0011815 increased pre-pro B cell number "increased number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]
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Allelic Composition: Flt3tm2.1Dosm/Flt3+
Genetic Background: B6.129(C)-Flt3tm2.1Dosm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000042817 Flt3 / fms related tyrosine kinase 3 / P36888*  / reaction / complex
 ENSMUSG00000110206 Flt3l / P49772 / Fms-related tyrosine kinase 3 ligand / FLT3LG* / P49771*  / complex / reaction






 

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