ENSMUSG00000110206


Mus musculus

Features
Gene ID: ENSMUSG00000110206
  
Biological name :Flt3l
  
Synonyms : Flt3l / Fms-related tyrosine kinase 3 ligand / P49772
  
Possible biological names infered from orthology : FLT3LG / P49771
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45129788
Gene end: 45136432
  
Corresponding Affymetrix probe sets: 10563116 (MoGene1.0st)   1422115_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147324
Ensembl peptide - ENSMUSP00000147468
Ensembl peptide - ENSMUSP00000148156
Ensembl peptide - ENSMUSP00000148009
Ensembl peptide - ENSMUSP00000147578
Ensembl peptide - ENSMUSP00000123506
Ensembl peptide - ENSMUSP00000147278
NCBI entrez gene - 14256     See in Manteia.
MGI - MGI:95560
RefSeq - XM_011250794
RefSeq - XM_006540606
RefSeq - XM_006540607
RefSeq - XM_006540608
RefSeq - XM_006540609
RefSeq - XM_006540610
RefSeq - XM_006540612
RefSeq - XM_011250793
RefSeq - NM_013520
RefSeq Peptide - NP_038548
swissprot - A0A1B0GRL9
swissprot - A0A1B0GRC9
swissprot - A0A1B0GSN6
swissprot - P49772
swissprot - Q8VCH4
swissprot - A9QW46
Ensembl - ENSMUSG00000110206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FLT3LGENSG00000090554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004213  Flt3 ligand
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030098 lymphocyte differentiation IMP
 biological_processGO:0030885 regulation of myeloid dendritic cell activation IMP
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IMP
 biological_processGO:0035162 embryonic hemopoiesis ISO
 biological_processGO:0045663 positive regulation of myoblast differentiation IMP
 biological_processGO:0045787 positive regulation of cell cycle IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IGI
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IGI
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IGI
 biological_processGO:0090290 positive regulation of osteoclast proliferation IGI
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031233 intrinsic component of external side of plasma membrane IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
PI3K Cascade
Other interleukin signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aw-15J/a
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0013649 decreased CD11b-high dendritic cell number "reduction in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0013655 decreased CD103-positive CD11b-low dendritic cell number "reduction in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [MGI:Saran, PMID:23516985]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000042817 Flt3 / fms related tyrosine kinase 3 / P36888*  / complex / reaction
 ENSMUSG00000110206 Flt3l / P49772 / Fms-related tyrosine kinase 3 ligand / FLT3LG* / P49771*  / complex






 

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