ENSG00000160867


Homo sapiens

Features
Gene ID: ENSG00000160867
  
Biological name :FGFR4
  
Synonyms : FGFR4 / fibroblast growth factor receptor 4 / P22455
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.2
Gene start: 177086886
Gene end: 177098144
  
Corresponding Affymetrix probe sets: 1554961_at (Human Genome U133 Plus 2.0 Array)   1554962_a_at (Human Genome U133 Plus 2.0 Array)   204579_at (Human Genome U133 Plus 2.0 Array)   211237_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395164
Ensembl peptide - ENSP00000422889
Ensembl peptide - ENSP00000427222
Ensembl peptide - ENSP00000426492
Ensembl peptide - ENSP00000424960
Ensembl peptide - ENSP00000424905
Ensembl peptide - ENSP00000424670
Ensembl peptide - ENSP00000292408
Ensembl peptide - ENSP00000377254
Ensembl peptide - ENSP00000377259
NCBI entrez gene - 2264     See in Manteia.
OMIM - 134935
RefSeq - XM_011534465
RefSeq - NM_001291980
RefSeq - NM_001354984
RefSeq - NM_002011
RefSeq - NM_022963
RefSeq - NM_213647
RefSeq - XM_005265838
RefSeq - XM_011534464
RefSeq Peptide - NP_075252
RefSeq Peptide - NP_998812
RefSeq Peptide - NP_001278909
RefSeq Peptide - NP_001341913
RefSeq Peptide - NP_002002
swissprot - J3KPQ0
swissprot - D6RJD4
swissprot - D6RG06
swissprot - D6R9V0
swissprot - B5A964
swissprot - P22455
swissprot - E7EWF4
swissprot - H0Y9P2
Ensembl - ENSG00000160867
  
Related genetic diseases (OMIM): 134935 - {Cancer progression/metastasis}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgfr4ENSDARG00000069105Danio rerio
 FGFR4ENSGALG00000028543Gallus gallus
 Fgfr4ENSMUSG00000005320Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGFR3 / P22607 / fibroblast growth factor receptor 3ENSG0000006807859
FGFR1 / P11362 / fibroblast growth factor receptor 1ENSG0000007778257
FGFR2 / P21802 / fibroblast growth factor receptor 2ENSG0000006646856
KDR / P35968 / kinase insert domain receptorENSG0000012805231
FLT1 / P17948 / fms related tyrosine kinase 1ENSG0000010275529
P09619 / PDGFRB / platelet derived growth factor receptor betaENSG0000011372129
FLT4 / P35916 / fms related tyrosine kinase 4ENSG0000003728029
CSF1R / P07333 / colony stimulating factor 1 receptorENSG0000018257828
RET / P07949 / ret proto-oncogeneENSG0000016573128
P16234 / PDGFRA / platelet derived growth factor receptor alphaENSG0000013485327
KIT / P10721 / KIT proto-oncogene receptor tyrosine kinaseENSG0000015740427
FLT3 / P36888 / fms related tyrosine kinase 3ENSG0000012202526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016248  Fibroblast growth factor receptor family
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IPI
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010715 regulation of extracellular matrix disassembly IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019216 regulation of lipid metabolic process ISS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0045862 positive regulation of proteolysis IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0055062 phosphate ion homeostasis ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070857 regulation of bile acid biosynthetic process IMP
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005007 fibroblast growth factor-activated receptor activity IGI
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
FGFR4 mutant receptor activation
FGFR4 ligand binding and activation
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
Signaling by FGFR4 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / complex / reaction
 ENSG00000137218 FRS3 / O43559 / fibroblast growth factor receptor substrate 3  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / reaction / complex
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction






 

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