ENSG00000137218


Homo sapiens

Features
Gene ID: ENSG00000137218
  
Biological name :FRS3
  
Synonyms : fibroblast growth factor receptor substrate 3 / FRS3 / O43559
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.1
Gene start: 41770176
Gene end: 41786542
  
Corresponding Affymetrix probe sets: 219907_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259748
Ensembl peptide - ENSP00000413214
Ensembl peptide - ENSP00000396715
Ensembl peptide - ENSP00000362109
NCBI entrez gene - 10817     See in Manteia.
OMIM - 607744
RefSeq - XM_011514254
RefSeq - XM_017010193
RefSeq - XM_011514255
RefSeq - NM_006653
RefSeq Peptide - NP_006644
swissprot - O43559
swissprot - A6PVU0
swissprot - A0A0A0MSM8
swissprot - A0A140VJJ7
Ensembl - ENSG00000137218
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frs3ENSDARG00000078688Danio rerio
 FRS3ENSGALG00000003447Gallus gallus
 Frs3ENSMUSG00000023266Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2ENSG0000016622549


Protein motifs (from Interpro)
Interpro ID Name
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
RAF/MAP kinase cascade
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / complex / reaction
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / complex / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000133116 KL / klotho / Q9UEF7  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / reaction / complex
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction






 

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