Manteia

ENSG00000128052

Homo sapiens

Features

Gene ID:	ENSG00000128052

Biological name :	KDR

Synonyms :	KDR / kinase insert domain receptor / P35968

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	4
Strand:	-1
Band:	q12
Gene start:	55078259
Gene end:	55125595

Corresponding Affymetrix probe sets:	203934_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000263923 Ensembl peptide - ENSP00000495159 NCBI entrez gene - 3791 See in Manteia. OMIM - 191306 RefSeq - NM_002253 RefSeq Peptide - NP_002244 swissprot - A0A024RD88 swissprot - P35968 Ensembl - ENSG00000128052

Related genetic diseases (OMIM):	602089 - Hemangioma, capillary infantile, somatic, 602089

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kdr	ENSDARG00000017321	Danio rerio
KDR	ENSGALG00000013907	Gallus gallus
Kdr	ENSMUSG00000062960	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
FLT1 / P17948 / fms related tyrosine kinase 1	ENSG00000102755	44
FLT4 / P35916 / fms related tyrosine kinase 4	ENSG00000037280	43
P16234 / PDGFRA / platelet derived growth factor receptor alpha	ENSG00000134853	23
P09619 / PDGFRB / platelet derived growth factor receptor beta	ENSG00000113721	22
KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase	ENSG00000157404	21
CSF1R / P07333 / colony stimulating factor 1 receptor	ENSG00000182578	21
FGFR2 / P21802 / fibroblast growth factor receptor 2	ENSG00000066468	19
FGFR1 / P11362 / fibroblast growth factor receptor 1	ENSG00000077782	19
FLT3 / P36888 / fms related tyrosine kinase 3	ENSG00000122025	19
FGFR3 / P22607 / fibroblast growth factor receptor 3	ENSG00000068078	19
RET / P07949 / ret proto-oncogene	ENSG00000165731	18
FGFR4 / P22455 / fibroblast growth factor receptor 4	ENSG00000160867	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR008266	Tyrosine-protein kinase, active site
IPR009136	Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR011009	Protein kinase-like domain superfamily
IPR013098	Immunoglobulin I-set
IPR013151	Immunoglobulin
IPR013783	Immunoglobulin-like fold
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	TAS
biological_process	GO:0001570	vasculogenesis	ISS
biological_process	GO:0001934	positive regulation of protein phosphorylation	IDA
biological_process	GO:0001938	positive regulation of endothelial cell proliferation	IMP
biological_process	GO:0002042	cell migration involved in sprouting angiogenesis	ISS
biological_process	GO:0003158	endothelium development	ISS
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0008360	regulation of cell shape	IDA
biological_process	GO:0010595	positive regulation of endothelial cell migration	IMP
biological_process	GO:0010629	negative regulation of gene expression	IDA
biological_process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016239	positive regulation of macroautophagy	IGI
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030198	extracellular matrix organization	TAS
biological_process	GO:0030335	positive regulation of cell migration	IMP
biological_process	GO:0035162	embryonic hemopoiesis	ISS
biological_process	GO:0035584	calcium-mediated signaling using intracellular calcium source	IMP
biological_process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IMP
biological_process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	IDA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISS
biological_process	GO:0038084	vascular endothelial growth factor signaling pathway	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0043410	positive regulation of MAPK cascade	IDA
biological_process	GO:0043491	protein kinase B signaling	IMP
biological_process	GO:0043536	positive regulation of blood vessel endothelial cell migration	IMP
biological_process	GO:0045766	positive regulation of angiogenesis	IMP
biological_process	GO:0046777	protein autophosphorylation	IDA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IMP
biological_process	GO:0050927	positive regulation of positive chemotaxis	IDA
biological_process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IMP
biological_process	GO:0051894	positive regulation of focal adhesion assembly	IDA
biological_process	GO:0051901	positive regulation of mitochondrial depolarization	IGI
biological_process	GO:0070371	ERK1 and ERK2 cascade	IMP
biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP
biological_process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IMP
biological_process	GO:0090141	positive regulation of mitochondrial fission	IGI
biological_process	GO:1904881	cellular response to hydrogen sulfide	IDA
biological_process	GO:2000352	negative regulation of endothelial cell apoptotic process	IDA
biological_process	GO:2001214	positive regulation of vasculogenesis	ISS
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005769	early endosome	ISS
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005794	Golgi apparatus	IDA
cellular_component	GO:0005886	plasma membrane	ISS
cellular_component	GO:0005887	integral component of plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	ISS
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0045121	membrane raft	IDA
cellular_component	GO:0097443	sorting endosome	ISS
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	EXP
molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	TAS
molecular_function	GO:0004716	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	TAS
molecular_function	GO:0005021	vascular endothelial growth factor-activated receptor activity	IDA
molecular_function	GO:0005178	integrin binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019838	growth factor binding	IPI
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0051879	Hsp90 protein binding	TAS

Pathways (from Reactome)

Pathway description

Neurophilin interactions with VEGF and VEGFR

VEGF binds to VEGFR leading to receptor dimerization

Integrin cell surface interactions

VEGFA-VEGFR2 Pathway

VEGFR2 mediated cell proliferation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
HP:0000006	Autosomal dominant inheritance	"A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]	Show
HP:0005306	Capillary hemangiomas	"The presence of a capillary hemangiomas, which are hemangiomas with small endothelial spaces." [HPO:curators]	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000050820	BCAR1 / P56945 / BCAR1, Cas family scaffolding protein	/ complex / reaction
ENSG00000080824	P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1	/ complex / reaction
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000089159	PXN / P49023 / paxillin	/ complex / reaction
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ reaction / complex
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ reaction / complex
ENSG00000120899	PTK2B / Q14289 / protein tyrosine kinase 2 beta	/ complex / reaction
ENSG00000167193	CRK / P46108 / CRK proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ complex / reaction
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ reaction / complex
ENSG00000105647	O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2	/ complex / reaction
ENSG00000167601	AXL / P30530 / AXL receptor tyrosine kinase	/ complex / reaction
ENSG00000071051	NCK2 / O43639 / NCK adaptor protein 2	/ reaction / complex
ENSG00000070831	CDC42 / P60953 / cell division cycle 42	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ reaction / complex
ENSG00000129946	SHC2 / P98077 / SHC adaptor protein 2	/ reaction / complex
ENSG00000169398	PTK2 / Q05397 / protein tyrosine kinase 2	/ complex / reaction
ENSG00000142798	HSPG2 / P98160 / heparan sulfate proteoglycan 2	/ reaction / complex
ENSG00000158092	NCK1 / P16333 / NCK adaptor protein 1	/ reaction / complex
ENSG00000155849	ELMO1 / Q92556 / engulfment and cell motility 1	/ complex / reaction
ENSG00000099250	NRP1 / O14786 / neuropilin 1	/ reaction / complex
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ reaction / complex
ENSG00000180370	PAK2 / Q13177 / p21 (RAC1) activated kinase 2	/ complex / reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ reaction / complex
ENSG00000107338	SHB / Q15464 / SH2 domain containing adaptor protein B	/ complex / reaction
ENSG00000138448	ITGAV / P06756 / integrin subunit alpha V	/ complex / reaction
ENSG00000259207	ITGB3 / P05106 / integrin subunit beta 3	/ complex / reaction
ENSG00000062598	ELMO2 / Q96JJ3 / engulfment and cell motility 2	/ reaction / complex
ENSG00000067560	RHOA / P61586 / ras homolog family member A	/ reaction
ENSG00000134318	ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2	/ reaction
ENSG00000165197	VEGFD / O43915 / vascular endothelial growth factor D	/ complex / reaction
ENSG00000027869	Q9NP31 / SH2D2A / SH2 domain containing 2A	/ complex / reaction
ENSG00000067900	ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1	/ reaction
ENSG00000150630	VEGFC / P49767 / vascular endothelial growth factor C	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr