ENSG00000067900


Homo sapiens

Features
Gene ID: ENSG00000067900
  
Biological name :ROCK1
  
Synonyms : Q13464 / Rho associated coiled-coil containing protein kinase 1 / ROCK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q11.1
Gene start: 20946906
Gene end: 21111851
  
Corresponding Affymetrix probe sets: 1561486_at (Human Genome U133 Plus 2.0 Array)   213044_at (Human Genome U133 Plus 2.0 Array)   214578_s_at (Human Genome U133 Plus 2.0 Array)   230239_at (Human Genome U133 Plus 2.0 Array)   235854_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462004
Ensembl peptide - ENSP00000489185
Ensembl peptide - ENSP00000382697
NCBI entrez gene - 6093     See in Manteia.
OMIM - 601702
RefSeq - NM_005406
RefSeq - XM_011526137
RefSeq Peptide - NP_005397
swissprot - A0A0U1RQV4
swissprot - J3KRH6
swissprot - Q13464
Ensembl - ENSG00000067900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rock1ENSDARG00000058993Danio rerio
 ROCK1ENSGALG00000014922Gallus gallus
 Rock1ENSMUSG00000024290Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2ENSG0000013431866
Q9Y5S2 / CDC42BPB / CDC42 binding protein kinase betaENSG0000019875228
Q5VT25 / CDC42BPA / CDC42 binding protein kinase alphaENSG0000014377627
Q6DT37 / CDC42BPG / CDC42 binding protein kinase gammaENSG0000017121925
CIT / O14578 / citron rho-interacting serine/threonine kinaseENSG0000012296625
DMPK / Q09013 / DM1 protein kinaseENSG0000010493614
LATS1 / O95835 / large tumor suppressor kinase 1ENSG0000013102312
STK38 / Q15208 / serine/threonine kinase 38ENSG0000011207912
Q9Y2H1 / STK38L / serine/threonine kinase 38 likeENSG0000021145512
LATS2 / Q9NRM7 / large tumor suppressor kinase 2ENSG0000015045712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029876  Rho-associated protein kinase 1
 IPR037310  Rho-associated protein kinase 1, HR1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003383 apical constriction IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006939 smooth muscle contraction TAS
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010506 regulation of autophagy TAS
 biological_processGO:0010508 positive regulation of autophagy IGI
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0022614 membrane to membrane docking IDA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030155 regulation of cell adhesion TAS
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0031175 neuron projection development IGI
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization TAS
 biological_processGO:0032970 regulation of actin filament-based process IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0045664 regulation of neuron differentiation IGI
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050900 leukocyte migration IDA
 biological_processGO:0050901 leukocyte tethering or rolling IDA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis TAS
 biological_processGO:0051451 myoblast migration IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0051893 regulation of focal adhesion assembly TAS
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0097194 execution phase of apoptosis TAS
 biological_processGO:0140058 neuron projection arborization IGI
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IGI
 biological_processGO:1900242 regulation of synaptic vesicle endocytosis IGI
 biological_processGO:1902003 regulation of amyloid-beta formation TAS
 biological_processGO:1902430 negative regulation of amyloid-beta formation IMP
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IMP
 biological_processGO:1903140 regulation of establishment of endothelial barrier IMP
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IGI
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0032059 bleb IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0106003 amyloid-beta complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / complex / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / reaction
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / reaction
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / reaction
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr