6093


Homo sapiens (NCBI)

Features
Gene ID: 6093
  
Biological name :
  
Synonyms : P160ROCK|ROCK-I / Rho associated coiled-coil containing protein kinase 1 / ROCK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 213044_at (Human Genome U133 Plus 2.0 Array)   214578_s_at (Human Genome U133 Plus 2.0 Array)   230239_at (Human Genome U133 Plus 2.0 Array)   235854_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 4885583
RefSeq - 767999131
RefSeq - NC_000018.10
RefSeq - NG_042178.2
RefSeq - NP_005397.1
RefSeq - XP_011524439.1
RefSeq - NM_005406.2
RefSeq - XM_011526137.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000067900 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003383 apical constriction IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006939 smooth muscle contraction TAS
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0007266 Rho protein signal transduction IGI
 biological_processGO:0010506 regulation of autophagy TAS
 biological_processGO:0010508 positive regulation of autophagy IGI
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0022614 membrane to membrane docking IDA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030155 regulation of cell adhesion TAS
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0031175 neuron projection development IGI
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization TAS
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0045664 regulation of neuron differentiation IGI
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050900 leukocyte migration IDA
 biological_processGO:0050901 leukocyte tethering or rolling IDA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis TAS
 biological_processGO:0051451 myoblast migration ISS
 biological_processGO:0051492 regulation of stress fiber assembly TAS
 biological_processGO:0051893 regulation of focal adhesion assembly TAS
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISS
 biological_processGO:0070168 negative regulation of biomineral tissue development ISS
 biological_processGO:0071559 response to transforming growth factor beta ISS
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0110061 regulation of angiotensin-activated signaling pathway IMP
 biological_processGO:0140058 neuron projection arborization IGI
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IGI
 biological_processGO:1900242 regulation of synaptic vesicle endocytosis IGI
 biological_processGO:1902003 regulation of amyloid-beta formation TAS
 biological_processGO:1902430 negative regulation of amyloid-beta formation IMP
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IMP
 biological_processGO:1903140 regulation of establishment of endothelial barrier IMP
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IGI
 biological_processGO:1905205 positive regulation of connective tissue replacement IMP
 biological_processGO:1990776 response to angiotensin ISS
 biological_processGO:2000114 regulation of establishment of cell polarity TAS
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0032059 bleb IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0106003 amyloid-beta complex IDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr