ENSG00000198752


Homo sapiens

Features
Gene ID: ENSG00000198752
  
Biological name :CDC42BPB
  
Synonyms : CDC42 binding protein kinase beta / CDC42BPB / Q9Y5S2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.32
Gene start: 102932379
Gene end: 103057462
  
Corresponding Affymetrix probe sets: 1557963_at (Human Genome U133 Plus 2.0 Array)   217849_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453384
Ensembl peptide - ENSP00000489452
Ensembl peptide - ENSP00000355237
NCBI entrez gene - 9578     See in Manteia.
OMIM - 614062
RefSeq - XM_011537387
RefSeq - NM_006035
RefSeq - XM_005268227
RefSeq - XM_005268228
RefSeq - XM_005268229
RefSeq - XM_005268230
RefSeq Peptide - NP_006026
swissprot - A0A0U1RRC3
swissprot - H0YLY0
swissprot - A0A024R6N2
swissprot - Q9Y5S2
Ensembl - ENSG00000198752
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc42bpaaENSDARG00000104283Danio rerio
 cdc42bpabENSDARG00000016464Danio rerio
 CDC42BPBENSGALG00000011432Gallus gallus
 Q7TT50ENSMUSG00000021279Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5VT25 / CDC42BPA / CDC42 binding protein kinase alphaENSG0000014377662
Q6DT37 / CDC42BPG / CDC42 binding protein kinase gammaENSG0000017121942
CIT / O14578 / citron rho-interacting serine/threonine kinaseENSG0000012296627
ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1ENSG0000006790022
ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2ENSG0000013431821
DMPK / Q09013 / DM1 protein kinaseENSG0000010493617
Q9Y2H1 / STK38L / serine/threonine kinase 38 likeENSG0000021145510
LATS2 / Q9NRM7 / large tumor suppressor kinase 2ENSG0000015045710
STK38 / Q15208 / serine/threonine kinase 38ENSG0000011207910
LATS1 / O95835 / large tumor suppressor kinase 1ENSG0000013102310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001180  Citron homology (CNH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014930  Myotonic dystrophy protein kinase, coiled coil
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR031597  KELK-motif containing domain
 IPR033232  Serine/threonine-protein kinase MRCK beta
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031032 actomyosin structure organization IMP
 biological_processGO:0031532 actin cytoskeleton reorganization ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge ISS
 cellular_componentGO:0042641 actomyosin IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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