ENSG00000143776


Homo sapiens

Features
Gene ID: ENSG00000143776
  
Biological name :CDC42BPA
  
Synonyms : CDC42 binding protein kinase alpha / CDC42BPA / Q5VT25
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.13
Gene start: 226989865
Gene end: 227318474
  
Corresponding Affymetrix probe sets: 203794_at (Human Genome U133 Plus 2.0 Array)   213595_s_at (Human Genome U133 Plus 2.0 Array)   214464_at (Human Genome U133 Plus 2.0 Array)   215296_at (Human Genome U133 Plus 2.0 Array)   240735_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407120
Ensembl peptide - ENSP00000401051
Ensembl peptide - ENSP00000408165
Ensembl peptide - ENSP00000415388
Ensembl peptide - ENSP00000335341
Ensembl peptide - ENSP00000355726
Ensembl peptide - ENSP00000355728
Ensembl peptide - ENSP00000355729
Ensembl peptide - ENSP00000355731
NCBI entrez gene - 8476     See in Manteia.
OMIM - 603412
RefSeq - XM_017002582
RefSeq - XM_006711835
RefSeq - XM_011544306
RefSeq - XM_011544307
RefSeq - XM_011544308
RefSeq - XM_011544309
RefSeq - XM_017002578
RefSeq - XM_017002579
RefSeq - XM_017002580
RefSeq - XM_017002581
RefSeq - NM_003607
RefSeq - NM_014826
RefSeq - XM_005273317
RefSeq - XM_005273318
RefSeq - XM_005273320
RefSeq - XM_005273321
RefSeq - XM_005273322
RefSeq - XM_005273324
RefSeq - XM_006711834
RefSeq Peptide - NP_003598
RefSeq Peptide - NP_055641
swissprot - H0Y6R0
swissprot - H0Y6V3
swissprot - A0A0A0MRJ1
swissprot - Q5VT25
swissprot - A0A0A0MRJ0
swissprot - H0Y7V8
swissprot - H0Y5V1
Ensembl - ENSG00000143776
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc42bpaaENSDARG00000104283Danio rerio
 cdc42bpabENSDARG00000016464Danio rerio
 CDC42BPAENSGALG00000009158Gallus gallus
 Q3UU96ENSMUSG00000026490Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y5S2 / CDC42BPB / CDC42 binding protein kinase betaENSG0000019875262
Q6DT37 / CDC42BPG / CDC42 binding protein kinase gammaENSG0000017121943
CIT / O14578 / citron rho-interacting serine/threonine kinaseENSG0000012296626
ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2ENSG0000013431821
ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1ENSG0000006790021
DMPK / Q09013 / DM1 protein kinaseENSG0000010493617
LATS2 / Q9NRM7 / large tumor suppressor kinase 2ENSG0000015045710
STK38 / Q15208 / serine/threonine kinase 38ENSG0000011207910
Q9Y2H1 / STK38L / serine/threonine kinase 38 likeENSG0000021145510
LATS1 / O95835 / large tumor suppressor kinase 1ENSG0000013102310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001180  Citron homology (CNH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014930  Myotonic dystrophy protein kinase, coiled coil
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR026611  Serine/threonine-protein kinase MRCK alpha
 IPR031597  KELK-motif containing domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031032 actomyosin structure organization IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0031252 cell leading edge ISS
 cellular_componentGO:0042641 actomyosin IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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