ENSG00000150457


Homo sapiens

Features
Gene ID: ENSG00000150457
  
Biological name :LATS2
  
Synonyms : large tumor suppressor kinase 2 / LATS2 / Q9NRM7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.11
Gene start: 20973032
Gene end: 21061547
  
Corresponding Affymetrix probe sets: 223379_s_at (Human Genome U133 Plus 2.0 Array)   223380_s_at (Human Genome U133 Plus 2.0 Array)   227013_at (Human Genome U133 Plus 2.0 Array)   230348_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000372035
NCBI entrez gene - 26524     See in Manteia.
OMIM - 604861
RefSeq - XM_017020542
RefSeq - NM_014572
RefSeq - XM_005266342
RefSeq - XM_011535042
RefSeq - XM_017020541
RefSeq Peptide - NP_055387
swissprot - Q9NRM7
swissprot - A0A024RDM3
Ensembl - ENSG00000150457
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lats2ENSDARG00000078864Danio rerio
 Lats2ENSMUSG00000114942Mus musculus
 Lats2ENSMUSG00000021959Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LATS1 / O95835 / large tumor suppressor kinase 1ENSG0000013102352
STK38 / Q15208 / serine/threonine kinase 38ENSG0000011207919
Q9Y2H1 / STK38L / serine/threonine kinase 38 likeENSG0000021145518
Q6DT37 / CDC42BPG / CDC42 binding protein kinase gammaENSG0000017121916
Q9Y5S2 / CDC42BPB / CDC42 binding protein kinase betaENSG0000019875216
Q5VT25 / CDC42BPA / CDC42 binding protein kinase alphaENSG0000014377616
ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1ENSG0000006790015
CIT / O14578 / citron rho-interacting serine/threonine kinaseENSG0000012296615
ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2ENSG0000013431815
DMPK / Q09013 / DM1 protein kinaseENSG0000010493613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035329 hippo signaling IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0046620 regulation of organ growth IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173542 MOB1B / Q7L9L4 / MOB kinase activator 1B  / complex / reaction
 ENSG00000101109 STK4 / Q13043 / serine/threonine kinase 4  / reaction
 ENSG00000114978 MOB1A / Q9H8S9 / MOB kinase activator 1A  / complex / reaction
 ENSG00000113645 WWC1 / Q8IX03 / WW and C2 domain containing 1  / complex / reaction
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / reaction
 ENSG00000131697 NPHP4 / O75161 / nephrocystin 4  / reaction / complex
 ENSG00000018408 WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1  / reaction
 ENSG00000104375 STK3 / Q13188 / serine/threonine kinase 3  / reaction






 

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