ENSMUSG00000114942


Mus musculus

Features
Gene ID: ENSMUSG00000114942
  
Biological name :Lats2
  
Synonyms : Lats2
  
Possible biological names infered from orthology : large tumor suppressor kinase 2 / Q9NRM7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 57642077
Gene end: 57746103
  
Corresponding Affymetrix probe sets: 1419679_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133680
MGI - MGI:1354386
MGI - MGI:6121571
swissprot - G3UXG3
Ensembl - ENSMUSG00000114942
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lats2ENSDARG00000078864Danio rerio
 LATS2ENSG00000150457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG00000021959100
Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*ENSMUSG0000004002151
Stk38 / Q91VJ4 / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA. / Q15208* / serine/threonine kinase 38*ENSMUSG0000002400616
Q7TSE6 / Stk38l / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA. / Q9Y2H1* / serine/threonine kinase 38 like*ENSMUSG0000000163015
Cit / citron rho-interacting serine/threonine kinase / O14578*ENSMUSG0000002951612
Q7TT50 / Cdc42bpb / CDC42 binding protein kinase beta / Q9Y5S2*ENSMUSG0000002127912
Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSMUSG0000002058012
Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*ENSMUSG0000002429012
Q3UU96 / Cdc42bpa / Serine/threonine-protein kinase MRCK alpha / Q5VT25* / CDC42 binding protein kinase alpha*ENSMUSG0000002649011
Q80UW5 / Cdc42bpg / Serine/threonine-protein kinase MRCK gamma / Q6DT37* / CDC42 binding protein kinase gamma*ENSMUSG0000002476911
Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*ENSMUSG0000003040911


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lats1tm1Noj/Lats1tm1Noj,Lats2tm1.1Dupa/Lats2tm1.1Dupa,Wwtr1tm1.2Eno/Wwtr1tm1.2Eno,Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

 MP:0000736 delayed muscle development "late onset of the induction and/or differentiation of skeletal muscle" [J:18048]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Lats2tm1Dgen/Lats2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

Allelic Composition: Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003707 increased nucleus count "greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Abca2tm1Nina/Abca2tm1Nina
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Lats2tm1Dgen/Lats2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Lats2tm1Noj/Lats2tm1Noj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013611 abnormal bile duct epithelium morphology "any structural anomaly of the epithelium lining the intrahepatic and extrahepatic bile ducts" [MGI:Anna]
Show

Allelic Composition: Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lats1tm1Noj/Lats1tm1Noj,Lats2tm1.1Dupa/Lats2tm1.1Dupa,Wwtr1tm1.2Eno/Wwtr1tm1.2Eno,Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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