ENSMUSG00000020580


Mus musculus

Features
Gene ID: ENSMUSG00000020580
  
Biological name :Rock2
  
Synonyms : Rho associated coiled-coil containing protein kinase 2 / Rock2
  
Possible biological names infered from orthology : O75116
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 16894895
Gene end: 16987823
  
Corresponding Affymetrix probe sets: 10394699 (MoGene1.0st)   1423592_at (Mouse Genome 430 2.0 Array)   1451041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152813
Ensembl peptide - ENSMUSP00000020904
Ensembl peptide - ENSMUSP00000152414
NCBI entrez gene - 19878     See in Manteia.
MGI - MGI:107926
RefSeq - XM_006515020
RefSeq - NM_009072
RefSeq - XM_006515019
RefSeq Peptide - NP_033098
swissprot - A0A1Y7VLD1
swissprot - F8VPK5
swissprot - A0A1Y7VMN0
Ensembl - ENSMUSG00000020580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rock2aENSDARG00000017500Danio rerio
 rock2bENSDARG00000004877Danio rerio
 rock2bENSDARG00000096433Danio rerio
 si:dkey-65b13.9ENSDARG00000105249Danio rerio
 ROCK2ENSGALG00000016451Gallus gallus
 ROCK2ENSG00000134318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*ENSMUSG0000002429064
Q7TT50 / Cdc42bpb / CDC42 binding protein kinase beta / Q9Y5S2*ENSMUSG0000002127926
Q3UU96 / Cdc42bpa / Serine/threonine-protein kinase MRCK alpha / Q5VT25* / CDC42 binding protein kinase alpha*ENSMUSG0000002649026
Cit / citron rho-interacting serine/threonine kinase / O14578*ENSMUSG0000002951624
Q80UW5 / Cdc42bpg / Serine/threonine-protein kinase MRCK gamma / Q6DT37* / CDC42 binding protein kinase gamma*ENSMUSG0000002476924
Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*ENSMUSG0000003040914
Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*ENSMUSG0000004002112
Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG0000002195912
Q7TSE6 / Stk38l / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA. / Q9Y2H1* / serine/threonine kinase 38 like*ENSMUSG0000000163011
Stk38 / Q91VJ4 / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA. / Q15208* / serine/threonine kinase 38*ENSMUSG0000002400611
Lats2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG000001149427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029878  Rho-associated protein kinase 2
 IPR037311  Rho-associated protein kinase 2, HR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010825 positive regulation of centrosome duplication IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0039694 viral RNA genome replication IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation IEA
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0150033 negative regulation of protein localization to lysosome IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1902966 positive regulation of protein localization to early endosome IEA
 biological_processGO:1902993 positive regulation of amyloid precursor protein catabolic process IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0072518 Rho-dependent protein serine/threonine kinase activity IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm19.1Sia/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005260 ocular hypotension "abnormally low intraocular pressure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm19.1Sia/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rock2Gt(OST440776)Lex/Rock2Gt(OST440776)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0012046 decreased susceptibility to hypertension "less likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [MGI:Nicole]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Sptbn1tm1c(EUCOMM)Wtsi/Sptbn1tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex






 

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