ENSDARG00000096433


Danio rerio

Features
Gene ID: ENSDARG00000096433
  
Biological name :rock2b
  
Synonyms : rho-associated, coiled-coil containing protein kinase 2b / rock2b
  
Possible biological names infered from orthology : O75116 / Rho associated coiled-coil containing protein kinase 2 / ROCK2
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 33571312
Gene end: 33583779
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000088595
swissprot - E7FDG0
ZFIN ID - ZDB-GENE-060125-2
Ensembl - ENSDARG00000096433
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROCK2ENSGALG00000016451Gallus gallus
 ROCK2ENSG00000134318Homo sapiens
 Rock2ENSMUSG00000020580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000000487799
rock2a / rho-associated, coiled-coil containing protein kinase 2a / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000001750058
rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*ENSDARG0000005899349
cdc42bpab / CDC42 binding protein kinase alpha (DMPK-like) b / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000001646418
cdc42bpb / CDC42 binding protein kinase beta (DMPK-like)ENSDARG0000001938317
cdc42bpaa / CDC42 binding protein kinase alpha (DMPK-like) a / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000010428316
citb / citron rho-interacting serine/threonine kinase b / CIT* / O14578* / citron rho-interacting serine/threonine kinase*ENSDARG0000008882516
cita / citron rho-interacting serine/threonine kinase aENSDARG0000008985615
lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *ENSDARG000000788642
lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSDARG000000037511
stk38b / serine/threonine kinase 38b / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG000000185161
stk38a / serine/threonine kinase 38a / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG000000199731
stk38l / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSDARG000000454820
si:dkey-65b13.9 / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG000001052490
DMPK / DM1 protein kinase / Q09013*ENSDARG000000749140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060287 epithelial cilium movement involved in determination of left/right asymmetry IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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